Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   OKL58_RS11725 Genome accession   NZ_CP109808
Coordinates   2486157..2487443 (+) Length   428 a.a.
NCBI ID   WP_264378641.1    Uniprot ID   -
Organism   Enterococcus hirae strain TF52     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2469835..2509666 2486157..2487443 within 0


Gene organization within MGE regions


Location: 2469835..2509666
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OKL58_RS11650 (OKL58_11655) - 2473278..2474186 (-) 909 WP_002332708.1 IS982-like element ISEfm1 family transposase -
  OKL58_RS11655 (OKL58_11660) - 2474381..2475334 (-) 954 WP_249488486.1 IS30 family transposase -
  OKL58_RS11660 (OKL58_11665) - 2475536..2476177 (-) 642 WP_002343741.1 HAD family phosphatase -
  OKL58_RS11665 (OKL58_11670) - 2476223..2476951 (-) 729 WP_002343742.1 hypothetical protein -
  OKL58_RS11670 (OKL58_11675) - 2476954..2477955 (-) 1002 WP_002343743.1 hypothetical protein -
  OKL58_RS11675 (OKL58_11680) - 2477972..2478781 (-) 810 WP_003126076.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  OKL58_RS11680 (OKL58_11685) - 2478771..2479556 (-) 786 WP_264378647.1 PTS sugar transporter subunit IIC -
  OKL58_RS11685 (OKL58_11690) - 2479572..2480042 (-) 471 WP_264378646.1 PTS sugar transporter subunit IIB -
  OKL58_RS11690 (OKL58_11695) - 2480057..2480476 (-) 420 WP_264378645.1 PTS sugar transporter subunit IIA -
  OKL58_RS11695 (OKL58_11700) - 2480611..2481327 (-) 717 WP_002343748.1 GntR family transcriptional regulator -
  OKL58_RS11700 (OKL58_11705) - 2481332..2481793 (-) 462 WP_002343749.1 hypothetical protein -
  OKL58_RS11705 (OKL58_11710) - 2482109..2482606 (-) 498 WP_264378644.1 hypothetical protein -
  OKL58_RS11710 (OKL58_11715) - 2482802..2483959 (-) 1158 WP_264378643.1 protein kinase domain-containing protein -
  OKL58_RS11715 (OKL58_11720) - 2484146..2485099 (-) 954 WP_264378642.1 IS30 family transposase -
  OKL58_RS11720 (OKL58_11725) rlmH 2485225..2485704 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  OKL58_RS11725 (OKL58_11730) htrA 2486157..2487443 (+) 1287 WP_264378641.1 S1C family serine protease Regulator
  OKL58_RS11730 (OKL58_11735) ytpR 2487501..2488106 (-) 606 WP_123874971.1 YtpR family tRNA-binding protein -
  OKL58_RS11735 (OKL58_11740) - 2488416..2488883 (-) 468 WP_002317107.1 universal stress protein -
  OKL58_RS11740 (OKL58_11745) - 2488913..2489233 (-) 321 WP_002317106.1 thioredoxin family protein -
  OKL58_RS11745 (OKL58_11750) pepA 2489650..2490729 (-) 1080 WP_010720947.1 glutamyl aminopeptidase -
  OKL58_RS11750 (OKL58_11755) - 2490928..2491281 (+) 354 WP_002317104.1 PepSY domain-containing protein -
  OKL58_RS11755 (OKL58_11760) - 2491453..2492409 (+) 957 WP_263746097.1 glycosyltransferase family 2 protein -
  OKL58_RS11760 (OKL58_11765) - 2492485..2493942 (-) 1458 WP_088745602.1 NAD-dependent succinate-semialdehyde dehydrogenase -
  OKL58_RS11765 (OKL58_11770) - 2494237..2495115 (+) 879 WP_088745601.1 cation diffusion facilitator family transporter -
  OKL58_RS11770 (OKL58_11775) - 2495180..2497050 (-) 1871 Protein_2309 glycosyltransferase -
  OKL58_RS11780 (OKL58_11785) - 2497240..2498544 (-) 1305 WP_264378640.1 glycosyltransferase family 2 protein -
  OKL58_RS11785 (OKL58_11790) - 2498519..2499052 (-) 534 WP_088745600.1 hypothetical protein -
  OKL58_RS11790 (OKL58_11795) - 2499346..2501481 (-) 2136 WP_088745599.1 UvrD-helicase domain-containing protein -
  OKL58_RS11795 (OKL58_11800) - 2501557..2503212 (-) 1656 WP_263746090.1 FAD-dependent oxidoreductase -
  OKL58_RS11800 (OKL58_11805) - 2503213..2503524 (-) 312 WP_181915136.1 rhodanese-like domain-containing protein -
  OKL58_RS11805 (OKL58_11810) - 2503696..2503956 (+) 261 WP_010737033.1 metal-sensitive transcriptional regulator -
  OKL58_RS11810 (OKL58_11815) - 2503969..2504280 (+) 312 WP_010720957.1 DsrE family protein -
  OKL58_RS11815 (OKL58_11820) - 2504422..2504970 (-) 549 WP_034867944.1 CDP-alcohol phosphatidyltransferase family protein -
  OKL58_RS11820 (OKL58_11825) - 2505174..2507072 (-) 1899 WP_123874965.1 endonuclease MutS2 -
  OKL58_RS11825 (OKL58_11830) - 2507585..2508301 (-) 717 WP_123874964.1 MIP/aquaporin family protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44630.75 Da        Isoelectric Point: 4.7976

>NTDB_id=749462 OKL58_RS11725 WP_264378641.1 2486157..2487443(+) (htrA) [Enterococcus hirae strain TF52]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITYAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=749462 OKL58_RS11725 WP_264378641.1 2486157..2487443(+) (htrA) [Enterococcus hirae strain TF52]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGTATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTCGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTAGAAGGGCAACAAGGGTTAGAAGTTTTATTAAAAGATGGTACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTAAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)

Trypsin-like peptidase domain (Trypsin_2)

(124-269)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453