Detailed information NTG0721368

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS35922_RS09930
• Genome accession: NZ_CP118097
• Coordinates: 2008791..2009531 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS35922
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2003791..2014531

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS35922_RS09905 (MGCS35922_04020)	-	2004149..2005444 (-)	1296	WP_065359151.1	DNA cytosine methyltransferase	-
MGCS35922_RS09910 (MGCS35922_04024)	-	2005588..2005860 (-)	273	WP_065957679.1	hypothetical protein	-
MGCS35922_RS09915 (MGCS35922_04026)	jag	2006171..2007085 (-)	915	WP_003056081.1	RNA-binding cell elongation regulator Jag/EloR	-
MGCS35922_RS09920 (MGCS35922_04028)	-	2007097..2007924 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
MGCS35922_RS09925 (MGCS35922_04030)	rnpA	2007890..2008249 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGCS35922_RS09930 (MGCS35922_04034)	comE/blpR	2008791..2009531 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
MGCS35922_RS09935 (MGCS35922_04036)	-	2009535..2010818 (-)	1284	WP_084916681.1	sensor histidine kinase	-
MGCS35922_RS09940 (MGCS35922_04038)	-	2010819..2012162 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
MGCS35922_RS09945 (MGCS35922_04040)	gltX	2012777..2014225 (-)	1449	WP_014612594.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=721368 MGCS35922_RS09930 WP_003061418.1 2008791..2009531(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35922]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=721368 MGCS35922_RS09930 WP_003061418.1 2008791..2009531(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35922]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394