Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EL263_RS06625 Genome accession   NZ_AP018938
Coordinates   1255441..1256178 (-) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae strain ATCC 49619     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1250441..1261178
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL263_RS06605 (SPAT_1255) msrB 1251900..1252838 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EL263_RS11810 - 1252905..1253057 (-) 153 WP_001835993.1 hypothetical protein -
  EL263_RS06615 (SPAT_1256) thrB 1253133..1254002 (-) 870 WP_000692438.1 homoserine kinase -
  EL263_RS06620 (SPAT_1257) - 1254004..1255290 (-) 1287 WP_000216375.1 homoserine dehydrogenase -
  EL263_RS06625 (SPAT_1258) mecA 1255441..1256178 (-) 738 WP_000782676.1 adaptor protein MecA Regulator
  EL263_RS06630 (SPAT_1259) - 1256378..1257412 (-) 1035 WP_000461498.1 hypothetical protein -
  EL263_RS06635 (SPAT_1260) - 1257441..1258874 (-) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  EL263_RS06640 (SPAT_1261) - 1258890..1259876 (-) 987 WP_054387437.1 glycosyltransferase family 2 protein -
  EL263_RS06645 (SPAT_1262) - 1259878..1260981 (-) 1104 WP_000225897.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=71945 EL263_RS06625 WP_000782676.1 1255441..1256178(-) (mecA) [Streptococcus pneumoniae strain ATCC 49619]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=71945 EL263_RS06625 WP_000782676.1 1255441..1256178(-) (mecA) [Streptococcus pneumoniae strain ATCC 49619]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment