Detailed information NTG0071918

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EL271_RS12035
• Genome accession: NZ_AP018937
• Coordinates: 457348..457935 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain HU-OH
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 452348..462935

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL271_RS02465 (SPOH_0446)	-	452809..454149 (+)	1341	WP_000275284.1	sensor histidine kinase	-
EL271_RS02470 (SPOH_0447)	blpC	454194..454349 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
EL271_RS02475 (SPOH_0448)	-	454406..455767 (-)	1362	WP_001069095.1	bacteriocin secretion accessory protein	-
EL271_RS02480 (SPOH_0450)	-	455778..457454 (-)	1677	Protein_458	peptide cleavage/export ABC transporter	-
EL271_RS12035 (SPOH_0451)	comA/nlmT	457348..457935 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EL271_RS02490 (SPOH_0452)	-	458225..458455 (+)	231	WP_001093270.1	hypothetical protein	-
EL271_RS02495 (SPOH_0453)	blpN	458471..458674 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
EL271_RS02505 (SPOH_0454)	-	458918..459151 (+)	234	WP_000379963.1	hypothetical protein	-
EL271_RS02510 (SPOH_0455)	-	459183..459872 (+)	690	WP_000760515.1	CPBP family intramembrane glutamic endopeptidase	-
EL271_RS02515 (SPOH_0456)	blpZ	459914..460147 (+)	234	WP_000276498.1	immunity protein BlpZ	-
EL271_RS02525 (SPOH_0457)	-	460298..460909 (+)	612	WP_000394028.1	CPBP family intramembrane glutamic endopeptidase	-
EL271_RS02530 (SPOH_0458)	ccrZ	461071..461865 (+)	795	WP_000363002.1	cell cycle regulator CcrZ	-
EL271_RS02535 (SPOH_0459)	trmB	461862..462497 (+)	636	WP_001266078.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=71918 EL271_RS12035 WP_000205166.1 457348..457935(-) (comA/nlmT) [Streptococcus pneumoniae strain HU-OH]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=71918 EL271_RS12035 WP_000205166.1 457348..457935(-) (comA/nlmT) [Streptococcus pneumoniae strain HU-OH]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497