Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   NWE23_RS05940 Genome accession   NZ_CP102746
Coordinates   1213544..1214248 (-) Length   234 a.a.
NCBI ID   WP_004298854.1    Uniprot ID   A0A0K2E6P6
Organism   Streptococcus suis strain Transconjugant cAKJ47-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1208544..1219248
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NWE23_RS05915 (NWE23_05925) - 1209419..1210168 (-) 750 WP_012027298.1 ATP-binding cassette domain-containing protein -
  NWE23_RS05920 (NWE23_05930) - 1210331..1210873 (-) 543 WP_012027299.1 ATP-binding cassette domain-containing protein -
  NWE23_RS05925 (NWE23_05935) - 1210981..1211136 (-) 156 WP_014636649.1 hypothetical protein -
  NWE23_RS05930 (NWE23_05940) vicX 1211392..1212195 (-) 804 WP_012027300.1 MBL fold metallo-hydrolase Regulator
  NWE23_RS05935 (NWE23_05945) micB 1212202..1213551 (-) 1350 WP_012027301.1 cell wall metabolism sensor histidine kinase VicK Regulator
  NWE23_RS05940 (NWE23_05950) micA 1213544..1214248 (-) 705 WP_004298854.1 response regulator YycF Regulator
  NWE23_RS05945 (NWE23_05955) - 1214442..1215203 (+) 762 WP_012027304.1 amino acid ABC transporter ATP-binding protein -
  NWE23_RS05950 (NWE23_05960) - 1215214..1216053 (+) 840 WP_012027305.1 transporter substrate-binding domain-containing protein -
  NWE23_RS05955 (NWE23_05965) - 1216068..1216766 (+) 699 WP_012028333.1 amino acid ABC transporter permease -
  NWE23_RS05960 (NWE23_05970) - 1216781..1217440 (+) 660 WP_002935828.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26781.77 Da        Isoelectric Point: 4.8957

>NTDB_id=718654 NWE23_RS05940 WP_004298854.1 1213544..1214248(-) (micA) [Streptococcus suis strain Transconjugant cAKJ47-2]
MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALEVFEAEFPDIVILDLMLPELDGLEVARTIRKTSNVPILMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRSELAETQTNIESTGTPELVIGDLVILPDAFVAKKHGKELELT
HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGND

Nucleotide


Download         Length: 705 bp        

>NTDB_id=718654 NWE23_RS05940 WP_004298854.1 1213544..1214248(-) (micA) [Streptococcus suis strain Transconjugant cAKJ47-2]
ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCAGATATTATTAAGTTTAATATGACGCGTGAGGGATATGA
AGTTGTGACAGCTTTCGATGGACGTGAAGCCTTGGAAGTATTTGAGGCTGAGTTTCCTGACATTGTCATTTTGGACTTGA
TGTTGCCAGAATTGGACGGACTAGAGGTTGCTCGAACGATTCGTAAGACCAGCAATGTTCCAATCTTGATGTTATCTGCT
AAAGATAGCGAATTTGATAAGGTTATCGGGCTTGAAATAGGGGCGGATGATTATGTGACCAAGCCCTTCTCTAATCGCGA
ATTACAGGCGCGTGTTAAGGCTCTTCTTCGTCGTAGTGAATTGGCAGAGACGCAGACAAATATTGAGTCAACAGGAACTC
CAGAGTTGGTGATTGGCGATTTGGTCATTCTGCCTGATGCGTTTGTTGCTAAGAAGCATGGTAAAGAGCTGGAGCTGACC
CATCGTGAGTTTGAATTGCTCCACCATCTGGCCAAACACTTAGGTCAGGTTATGACTCGAGAACATCTATTGGAAACAGT
TTGGGGTTATGATTACTTTGGTGATGTCCGCACGGTGGATGTAACGATTCGTCGTCTGCGTGAGAAAATTGAAGATACAC
CAAGCAGACCAGAATACATTCTTACTCGTCGCGGAGTGGGATATTTTATAAAAGGAAATGATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0K2E6P6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

81.974

99.573

0.816
  vicR Streptococcus mutans UA159

80.426

100

0.808
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.783

98.291

0.44
  covR Streptococcus salivarius strain HSISS4

43.723

98.718

0.432
  scnR Streptococcus mutans UA159

38.095

98.718

0.376