Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   EL277_RS10535 Genome accession   NZ_AP018936
Coordinates   1969771..1970724 (-) Length   317 a.a.
NCBI ID   WP_000345135.1    Uniprot ID   A0A2U3RW99
Organism   Streptococcus pneumoniae strain NU83127     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1964771..1975724
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS10510 (SPNU_1985) - 1965532..1966155 (-) 624 WP_000932644.1 hypothetical protein -
  EL277_RS10515 (SPNU_1986) jag 1966206..1967192 (-) 987 WP_000260012.1 RNA-binding cell elongation regulator Jag/EloR -
  EL277_RS10520 (SPNU_1987) - 1967211..1968035 (-) 825 WP_000727904.1 membrane protein insertase YidC -
  EL277_RS10525 (SPNU_1988) rnpA 1968010..1968381 (-) 372 WP_000739253.1 ribonuclease P protein component -
  EL277_RS12635 - 1968398..1968529 (-) 132 WP_000768904.1 hypothetical protein -
  EL277_RS10530 (SPNU_1989) - 1968530..1969720 (-) 1191 WP_000167757.1 acetate kinase -
  EL277_RS10535 (SPNU_1990) comYH 1969771..1970724 (-) 954 WP_000345135.1 class I SAM-dependent methyltransferase Machinery gene
  EL277_RS10540 - 1970785..1971379 (-) 595 Protein_1954 class I SAM-dependent methyltransferase -
  EL277_RS10545 (SPNU_1993) comGG/cglG 1971516..1971929 (-) 414 WP_000265622.1 competence type IV pilus minor pilin ComGG Machinery gene
  EL277_RS10550 (SPNU_1994) comGF/cglF 1971907..1972368 (-) 462 WP_000250534.1 competence type IV pilus minor pilin ComGF Machinery gene
  EL277_RS10555 (SPNU_1995) comGE/cglE 1972331..1972633 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  EL277_RS10560 (SPNU_1996) comGD/cglD 1972596..1973000 (-) 405 WP_000588028.1 competence type IV pilus minor pilin ComGD Machinery gene
  EL277_RS10565 (SPNU_1997) comGC/cglC 1972993..1973319 (-) 327 WP_000738627.1 comG operon protein ComGC Machinery gene
  EL277_RS10570 (SPNU_1998) comGB/cglB 1973321..1974337 (-) 1017 WP_074196785.1 competence type IV pilus assembly protein ComGB Machinery gene
  EL277_RS10575 (SPNU_1999) comGA/cglA/cilD 1974285..1975226 (-) 942 WP_000249564.1 competence type IV pilus ATPase ComGA Machinery gene
  EL277_RS10580 (SPNU_2000) - 1975302..1975667 (-) 366 WP_000286415.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35756.99 Da        Isoelectric Point: 4.2748

>NTDB_id=71820 EL277_RS10535 WP_000345135.1 1969771..1970724(-) (comYH) [Streptococcus pneumoniae strain NU83127]
MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKENNQTLKRLALRKEEWLKTYQFLLMKAGQT
EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGAIFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ
AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ
SDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFILQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

Nucleotide


Download         Length: 954 bp        

>NTDB_id=71820 EL277_RS10535 WP_000345135.1 1969771..1970724(-) (comYH) [Streptococcus pneumoniae strain NU83127]
ATGGATTTTGAAAAAATTGAACAAGCTTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA
CTTTTATGACGCCTTGGTGGAGCAAAATAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAGGAGAACAATC
AAACCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA
GAACCCTTGCAGGCCAATCACCAGTTTACACCGGATGCTATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA
AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTATTTTCTTGACCTCGCTTACTAAAA
AGGTGGATTACTTGGGAATGGAAGTGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG
GCTGGCTTTGTCCAAGGAGATGCCGTTCGCCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTCGG
CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA
TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA
AGTGATTTGTTAAAAGAATGGCTGAAAGAAGAGGCGAGTCTGGTTGCTATGATTAGTCTGCCTGAAAATCTCTTTGCTAA
TGCCAAACAATCTAAGACTATTTTTATCTTACAGAAGAAAAATGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA
GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(69-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2U3RW99

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA140

54.633

98.738

0.539
  comYH Streptococcus mutans UA159

54.313

98.738

0.536

Multiple sequence alignment