Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EL277_RS06735 Genome accession   NZ_AP018936
Coordinates   1281175..1281912 (-) Length   245 a.a.
NCBI ID   WP_000782668.1    Uniprot ID   Q97Q68
Organism   Streptococcus pneumoniae strain NU83127     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1276175..1286912
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS06715 (SPNU_1279) msrB 1277634..1278572 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EL277_RS12335 - 1278639..1278791 (-) 153 WP_001835993.1 hypothetical protein -
  EL277_RS06725 (SPNU_1280) thrB 1278867..1279736 (-) 870 WP_000692438.1 homoserine kinase -
  EL277_RS06730 (SPNU_1281) - 1279738..1281024 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  EL277_RS06735 (SPNU_1282) mecA 1281175..1281912 (-) 738 WP_000782668.1 adaptor protein MecA Regulator
  EL277_RS06740 (SPNU_1283) - 1282112..1283146 (-) 1035 WP_000461503.1 hypothetical protein -
  EL277_RS06745 (SPNU_1284) - 1283175..1284608 (-) 1434 WP_000565078.1 O-antigen polysaccharide polymerase Wzy family protein -
  EL277_RS06750 (SPNU_1285) - 1284624..1285610 (-) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  EL277_RS06755 (SPNU_1286) - 1285612..1286715 (-) 1104 WP_000225907.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28391.20 Da        Isoelectric Point: 4.0199

>NTDB_id=71794 EL277_RS06735 WP_000782668.1 1281175..1281912(-) (mecA) [Streptococcus pneumoniae strain NU83127]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEVKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=71794 EL277_RS06735 WP_000782668.1 1281175..1281912(-) (mecA) [Streptococcus pneumoniae strain NU83127]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGTCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q97Q68

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae TIGR4

100

100

1
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus thermophilus LMD-9

48.594

100

0.494
  mecA Streptococcus thermophilus LMG 18311

48.193

100

0.49
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment