Detailed information NTG0071778

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL277_RS02675
• Genome accession: NZ_AP018936
• Coordinates: 511088..511825 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219119.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain NU83127
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 506088..516825

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL277_RS02635	-	507063..507257 (-)	195	WP_001827223.1	hypothetical protein	-
EL277_RS02640 (SPNU_0496)	-	507419..507706 (-)	288	WP_000777753.1	hypothetical protein	-
EL277_RS02645 (SPNU_0497)	-	507716..508126 (-)	411	WP_001278301.1	HIT family protein	-
EL277_RS02650 (SPNU_0498)	pptA	508194..508925 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
EL277_RS02655 (SPNU_0499)	-	508922..509971 (+)	1050	WP_000653773.1	ABC transporter permease	-
EL277_RS02665 (SPNU_0500)	-	510139..510468 (-)	330	WP_000132572.1	hypothetical protein	-
EL277_RS02670 (SPNU_0501)	-	510745..511083 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
EL277_RS02675 (SPNU_0502)	comE/blpR	511088..511825 (+)	738	WP_001219119.1	response regulator transcription factor	Regulator
EL277_RS02680 (SPNU_0504)	-	511839..513168 (+)	1330	Protein_503	sensor histidine kinase	-
EL277_RS02685 (SPNU_0505)	blpC	513212..513367 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
EL277_RS02690 (SPNU_0506)	-	513424..514785 (-)	1362	WP_001069103.1	bacteriocin secretion accessory protein	-
EL277_RS12645 (SPNU_0507)	comA/nlmT	514796..515707 (-)	912	WP_001827226.1	ATP-binding cassette domain-containing protein	Regulator
EL277_RS12650 (SPNU_0508)	comA/nlmT	515697..516422 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28706.89 Da
• Isoelectric Point: 6.4140

>NTDB_id=71778 EL277_RS02675 WP_001219119.1 511088..511825(+) (comE/blpR) [Streptococcus pneumoniae strain NU83127]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=71778 EL277_RS02675 WP_001219119.1 511088..511825(+) (comE/blpR) [Streptococcus pneumoniae strain NU83127]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.036	100	0.535
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38