Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   NUU05_RS08865 Genome accession   NZ_CP102538
Coordinates   1695854..1696543 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain TH-4     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1690854..1701543
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NUU05_RS08845 (NUU05_08810) dnaI 1691661..1692563 (-) 903 WP_011680740.1 primosomal protein DnaI -
  NUU05_RS08850 (NUU05_08815) - 1692567..1693742 (-) 1176 WP_011680739.1 DnaD domain protein -
  NUU05_RS08855 (NUU05_08820) nrdR 1693739..1694218 (-) 480 WP_011680738.1 transcriptional regulator NrdR -
  NUU05_RS08860 (NUU05_08825) covS 1694340..1695857 (-) 1518 WP_002949640.1 HAMP domain-containing histidine kinase Regulator
  NUU05_RS08865 (NUU05_08830) covR 1695854..1696543 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  NUU05_RS08870 (NUU05_08835) - 1696699..1697235 (-) 537 WP_002946488.1 DUF177 domain-containing protein -
  NUU05_RS08875 (NUU05_08840) rsmG 1697532..1698245 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  NUU05_RS08880 (NUU05_08845) - 1698315..1699679 (+) 1365 WP_011680735.1 TrkH family potassium uptake protein -
  NUU05_RS08885 (NUU05_08850) - 1699719..1700390 (+) 672 WP_002946492.1 TrkA family potassium uptake protein -
  NUU05_RS08890 (NUU05_08855) - 1700407..1700577 (-) 171 Protein_1686 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=717651 NUU05_RS08865 WP_002949638.1 1695854..1696543(-) (covR) [Streptococcus thermophilus strain TH-4]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=717651 NUU05_RS08865 WP_002949638.1 1695854..1696543(-) (covR) [Streptococcus thermophilus strain TH-4]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACTTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441