Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   NUU05_RS08860 Genome accession   NZ_CP102538
Coordinates   1694340..1695857 (-) Length   505 a.a.
NCBI ID   WP_002949640.1    Uniprot ID   A0A060BQ50
Organism   Streptococcus thermophilus strain TH-4     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1689340..1700857
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NUU05_RS09830 - 1689522..1690181 (-) 660 Protein_1675 HI_0552 family protein -
  NUU05_RS08840 (NUU05_08805) der 1690245..1691555 (-) 1311 WP_011680741.1 ribosome biogenesis GTPase Der -
  NUU05_RS08845 (NUU05_08810) dnaI 1691661..1692563 (-) 903 WP_011680740.1 primosomal protein DnaI -
  NUU05_RS08850 (NUU05_08815) - 1692567..1693742 (-) 1176 WP_011680739.1 DnaD domain protein -
  NUU05_RS08855 (NUU05_08820) nrdR 1693739..1694218 (-) 480 WP_011680738.1 transcriptional regulator NrdR -
  NUU05_RS08860 (NUU05_08825) covS 1694340..1695857 (-) 1518 WP_002949640.1 HAMP domain-containing histidine kinase Regulator
  NUU05_RS08865 (NUU05_08830) covR 1695854..1696543 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  NUU05_RS08870 (NUU05_08835) - 1696699..1697235 (-) 537 WP_002946488.1 DUF177 domain-containing protein -
  NUU05_RS08875 (NUU05_08840) rsmG 1697532..1698245 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  NUU05_RS08880 (NUU05_08845) - 1698315..1699679 (+) 1365 WP_011680735.1 TrkH family potassium uptake protein -
  NUU05_RS08885 (NUU05_08850) - 1699719..1700390 (+) 672 WP_002946492.1 TrkA family potassium uptake protein -
  NUU05_RS08890 (NUU05_08855) - 1700407..1700577 (-) 171 Protein_1686 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57536.93 Da        Isoelectric Point: 5.2689

>NTDB_id=717650 NUU05_RS08860 WP_002949640.1 1694340..1695857(-) (covS) [Streptococcus thermophilus strain TH-4]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=717650 NUU05_RS08860 WP_002949640.1 1694340..1695857(-) (covS) [Streptococcus thermophilus strain TH-4]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BQ50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.622

99.406

0.941