Detailed information NTG0717546

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGGS36055_RS09905
• Genome accession: NZ_CP117286
• Coordinates: 1983704..1984444 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGGS36055
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1978704..1989444

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGGS36055_RS09880 (MGGS36055_03984)	-	1979602..1980306 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGGS36055_RS09885 (MGGS36055_03986)	rpmH	1980637..1980771 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGGS36055_RS09890 (MGGS36055_03988)	jag	1981084..1981998 (-)	915	WP_015017424.1	RNA-binding cell elongation regulator Jag/EloR	-
MGGS36055_RS09895 (MGGS36055_03990)	-	1982010..1982837 (-)	828	WP_015017425.1	YidC/Oxa1 family membrane protein insertase	-
MGGS36055_RS09900 (MGGS36055_03992)	rnpA	1982803..1983162 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGGS36055_RS09905 (MGGS36055_03996)	comE/blpR	1983704..1984444 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
MGGS36055_RS09910 (MGGS36055_03998)	-	1984448..1985731 (-)	1284	WP_015017426.1	sensor histidine kinase	-
MGGS36055_RS09915 (MGGS36055_04000)	-	1985732..1987075 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
MGGS36055_RS09920 (MGGS36055_04002)	gltX	1987690..1989138 (-)	1449	WP_003053372.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=717546 MGGS36055_RS09905 WP_003061418.1 1983704..1984444(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGGS36055]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=717546 MGGS36055_RS09905 WP_003061418.1 1983704..1984444(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGGS36055]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCAATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAGGACATGTTTCTATTTGAGACTCCTCAGACAAGATTGAAACTACCTTACAAAGATATCCTT
TATTTTGCCACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394