Detailed information NTG0717339

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS36089_RS09535
• Genome accession: NZ_CP117284
• Coordinates: 1936628..1937368 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS36089
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1931628..1942368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS36089_RS09510 (MGCS36089_03868)	-	1932525..1933229 (-)	705	WP_110408179.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGCS36089_RS09515 (MGCS36089_03870)	rpmH	1933560..1933694 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGCS36089_RS09520 (MGCS36089_03872)	jag	1934008..1934922 (-)	915	WP_003062632.1	RNA-binding cell elongation regulator Jag/EloR	-
MGCS36089_RS09525 (MGCS36089_03874)	-	1934934..1935761 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
MGCS36089_RS09530 (MGCS36089_03876)	rnpA	1935727..1936086 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGCS36089_RS09535 (MGCS36089_03880)	comE/blpR	1936628..1937368 (-)	741	WP_003061418.1	response regulator transcription factor	Regulator
MGCS36089_RS09540 (MGCS36089_03882)	-	1937372..1938655 (-)	1284	WP_084916681.1	sensor histidine kinase	-
MGCS36089_RS09545 (MGCS36089_03884)	-	1938656..1939959 (-)	1304	Protein_1821	sensor histidine kinase	-
MGCS36089_RS09550 (MGCS36089_03886)	gltX	1940574..1942022 (-)	1449	WP_003053372.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=717339 MGCS36089_RS09535 WP_003061418.1 1936628..1937368(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS36089]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=717339 MGCS36089_RS09535 WP_003061418.1 1936628..1937368(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS36089]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394