Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NPS17_RS05225 Genome accession   NZ_CP101985
Coordinates   1155107..1155781 (-) Length   224 a.a.
NCBI ID   WP_002264509.1    Uniprot ID   -
Organism   Streptococcus mutans strain COCC33-14R     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1150107..1160781
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS17_RS05200 (NPS17_05200) - 1150415..1151692 (-) 1278 WP_258968806.1 pyrimidine-nucleoside phosphorylase -
  NPS17_RS05205 (NPS17_05205) - 1151801..1152397 (-) 597 WP_019323635.1 class I SAM-dependent methyltransferase -
  NPS17_RS05210 (NPS17_05210) coaA 1152493..1153413 (+) 921 WP_002262217.1 type I pantothenate kinase -
  NPS17_RS05215 (NPS17_05215) rpsT 1153467..1153721 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  NPS17_RS05220 (NPS17_05220) ciaH 1153810..1155117 (-) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  NPS17_RS05225 (NPS17_05225) ciaR 1155107..1155781 (-) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  NPS17_RS05230 (NPS17_05230) ciaX 1155832..1156095 (-) 264 WP_002281780.1 three-component system regulator CiaX -
  NPS17_RS05235 (NPS17_05235) - 1156497..1159046 (-) 2550 WP_082999550.1 M1 family metallopeptidase -
  NPS17_RS05240 (NPS17_05240) phoU 1159087..1159740 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  NPS17_RS05245 (NPS17_05245) pstB 1159772..1160530 (-) 759 WP_002262210.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25417.19 Da        Isoelectric Point: 4.3777

>NTDB_id=713577 NPS17_RS05225 WP_002264509.1 1155107..1155781(-) (ciaR) [Streptococcus mutans strain COCC33-14R]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=713577 NPS17_RS05225 WP_002264509.1 1155107..1155781(-) (ciaR) [Streptococcus mutans strain COCC33-14R]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGCAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

35.622

100

0.371