Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   K6J60_RS03160 Genome accession   NZ_AP018778
Coordinates   617772..619109 (+) Length   445 a.a.
NCBI ID   WP_005662594.1    Uniprot ID   A0A0D0IIU1
Organism   Haemophilus influenzae strain CHBN-III-7 isolate 15H01     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 612772..624109
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6J60_RS03135 (CHBNIII7_05910) - 612837..615431 (-) 2595 WP_221267425.1 penicillin-binding protein 1A -
  K6J60_RS03140 (CHBNIII7_05920) comA 615530..616327 (+) 798 WP_042601084.1 pilus assembly protein PilM Machinery gene
  K6J60_RS03145 (CHBNIII7_05930) comB 616328..616834 (+) 507 WP_005656467.1 competence protein ComB Machinery gene
  K6J60_RS03150 (CHBNIII7_05940) comC 616831..617352 (+) 522 WP_005662592.1 competence protein ComC Machinery gene
  K6J60_RS03155 (CHBNIII7_05950) comD 617349..617762 (+) 414 WP_005662593.1 pilus assembly protein PilP Machinery gene
  K6J60_RS03160 (CHBNIII7_05960) comE 617772..619109 (+) 1338 WP_005662594.1 type IV pilus secretin PilQ family protein Machinery gene
  K6J60_RS03165 (CHBNIII7_05970) - 619122..619808 (+) 687 WP_118801578.1 ComF family protein -
  K6J60_RS03170 (CHBNIII7_05980) nfuA 619884..620480 (+) 597 WP_105896093.1 Fe-S biogenesis protein NfuA -
  K6J60_RS03175 (CHBNIII7_05990) nudC 620548..621342 (+) 795 WP_221267426.1 NAD(+) diphosphatase -
  K6J60_RS03180 (CHBNIII7_06000) - 621378..621968 (+) 591 WP_048954881.1 YjaG family protein -
  K6J60_RS03185 (CHBNIII7_06010) - 622108..622380 (+) 273 WP_005630954.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49166.51 Da        Isoelectric Point: 8.2628

>NTDB_id=71211 K6J60_RS03160 WP_005662594.1 617772..619109(+) (comE) [Haemophilus influenzae strain CHBN-III-7 isolate 15H01]
MKKYLLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTVEQLAFQQDVNLVMGERLEGNISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGVYYLNGSQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPVGSITFDDRSN
LLVIQDEPRFVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLTGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=71211 K6J60_RS03160 WP_005662594.1 617772..619109(+) (comE) [Haemophilus influenzae strain CHBN-III-7 isolate 15H01]
ATGAAGAAATATCTTTTAAAGTGCGGTTATTTTTTAGTATGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACAGTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATGGGTGAGAGGTTAGAAGGCAATATTTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGGTTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TCAGGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACAACAGGAAGTGGATCTTTGCTTTCTCCTGTGGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTTTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTTACAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCAAGCA
TTAAACAGGGGACAGAAATTCCTTACGTCGTGAGTAATACTCGTAACGATACGCAGTCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTAGTGATTTTCGTCACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGGAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)

Bacterial type II and III secretion system protein (Secretin)

(269-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D0IIU1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae 86-028NP

98.652

100

0.987
  comE Haemophilus influenzae Rd KW20

97.079

100

0.971
  comE Glaesserella parasuis strain SC1401

52

95.506

0.497
  pilQ Vibrio campbellii strain DS40M4

42.721

94.157

0.402
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.99

92.584

0.389
  pilQ Vibrio cholerae strain A1552

41.99

92.584

0.389

Multiple sequence alignment