Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   NNL98_RS08885 Genome accession   NZ_CP101537
Coordinates   1861116..1863278 (-) Length   720 a.a.
NCBI ID   WP_011254576.1    Uniprot ID   Q5FI74
Organism   Lactobacillus acidophilus strain HN017     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1856116..1868278
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NNL98_RS08830 (NNL98_08815) - 1856159..1856581 (-) 423 WP_003549784.1 hypothetical protein -
  NNL98_RS08835 (NNL98_08820) - 1856615..1856809 (-) 195 WP_003549781.1 hypothetical protein -
  NNL98_RS08840 (NNL98_08825) - 1856942..1857151 (-) 210 WP_003549779.1 helix-turn-helix transcriptional regulator -
  NNL98_RS08845 (NNL98_08830) - 1857166..1857705 (-) 540 WP_021874284.1 hypothetical protein -
  NNL98_RS08850 (NNL98_08835) - 1857710..1857892 (-) 183 WP_003549768.1 hypothetical protein -
  NNL98_RS08855 (NNL98_08840) - 1858089..1858304 (-) 216 WP_003549767.1 hypothetical protein -
  NNL98_RS08860 (NNL98_08845) - 1858322..1858477 (-) 156 WP_003549765.1 hypothetical protein -
  NNL98_RS08865 (NNL98_08850) - 1858481..1858675 (-) 195 WP_003549764.1 hypothetical protein -
  NNL98_RS08870 (NNL98_08855) - 1858841..1859032 (-) 192 WP_003549761.1 hypothetical protein -
  NNL98_RS08875 (NNL98_08860) - 1859033..1860349 (-) 1317 WP_003549759.1 LPXTG cell wall anchor domain-containing protein -
  NNL98_RS08880 (NNL98_08865) - 1860515..1861105 (-) 591 WP_003549757.1 hypothetical protein -
  NNL98_RS08885 (NNL98_08870) comA 1861116..1863278 (-) 2163 WP_011254576.1 peptide cleavage/export ABC transporter Regulator
  NNL98_RS08890 (NNL98_08875) - 1863471..1863875 (-) 405 WP_003549753.1 hypothetical protein -
  NNL98_RS08895 (NNL98_08880) - 1863909..1864160 (-) 252 WP_003549751.1 bacteriocin class II family protein -
  NNL98_RS08900 (NNL98_08885) - 1864353..1865153 (-) 801 WP_021721605.1 LytTR family DNA-binding domain-containing protein -
  NNL98_RS08905 (NNL98_08890) - 1865146..1866132 (-) 987 WP_015613420.1 GHKL domain-containing protein -
  NNL98_RS08910 (NNL98_08895) - 1866475..1866618 (-) 144 WP_003549744.1 bacteriocin-like peptide, LSEI_2386 family -
  NNL98_RS08915 (NNL98_08900) - 1866749..1866940 (-) 192 WP_011254579.1 hypothetical protein -
  NNL98_RS08920 (NNL98_08905) - 1867053..1867214 (-) 162 WP_003549740.1 hypothetical protein -
  NNL98_RS08925 (NNL98_08910) - 1867386..1868012 (-) 627 WP_003549738.1 hypothetical protein -
  NNL98_RS08930 (NNL98_08915) - 1868068..1868244 (-) 177 WP_003549735.1 hypothetical protein -

Sequence

Protein


Download         Length: 720 a.a.        Molecular weight: 81336.61 Da        Isoelectric Point: 8.0981

>NTDB_id=710490 NNL98_RS08885 WP_011254576.1 1861116..1863278(-) (comA) [Lactobacillus acidophilus strain HN017]
MLLQYKSIYVPQVDESDCGVACLAMILKKYHSRVSLAHLRHSARTNLEGTTALGLVKTAQTFNLKTEAVKADMSLFDPDT
DIQYPFIVHVLKQGELLHYYVVLKATKNYLVIADPDPSVGLTKMSKEKFSQEWTGIALFMVPNDDFEPVKEKKRNLWSLF
PYMFKQKKLVTNIILAALLMTIISICSSYFLQGLIDTYIPNGTYQTLSILAIGLLIAYVFNSIFSYGQNFLLNILGQRLS
IDLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGIVLAIQNSTLFMITLLALPVY
AVVILSFSKKFEKLNNDQMESNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTFI
QLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQNRLNEVYMVKSEFQKDVQIRDAK
QLVGDIEYHNVDYHYGYGVDVLKDVNLKIKQNDKLAIVGMSGSGKSTMVKLLVDFFSPSKGKLTFNGFDSTKVDKHVLRS
YVNYVPQTPYIFSGTIKENLLLGSRPDITEEDVLKACQIAEIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLS
PAKVLIFDEATSGLDTITEKKVVDNLMKLKNKTIIFIAHRLAIAQRTNNIVVVDHGQIVEQGSHDELMQKHGFYYNLVEN

Nucleotide


Download         Length: 2163 bp        

>NTDB_id=710490 NNL98_RS08885 WP_011254576.1 1861116..1863278(-) (comA) [Lactobacillus acidophilus strain HN017]
ATGCTACTACAATATAAATCAATCTATGTACCACAAGTAGACGAATCAGATTGCGGTGTTGCCTGTTTGGCTATGATTCT
TAAGAAATATCATTCTAGAGTATCATTAGCACATTTGCGCCATTCAGCACGTACTAATTTAGAAGGAACTACCGCCCTTG
GCTTAGTCAAAACAGCACAAACATTTAATTTGAAAACTGAAGCGGTCAAAGCTGATATGTCCTTGTTTGATCCAGATACG
GATATCCAATATCCTTTTATTGTTCATGTCTTAAAACAAGGCGAATTACTCCACTATTATGTTGTACTTAAAGCAACTAA
AAATTATTTAGTAATTGCTGATCCAGATCCTAGCGTTGGTTTAACGAAAATGTCTAAAGAAAAATTCTCTCAAGAATGGA
CTGGTATTGCCCTTTTTATGGTTCCTAATGACGATTTTGAGCCAGTTAAGGAGAAAAAACGAAATCTTTGGTCGTTGTTT
CCATATATGTTCAAGCAAAAGAAATTAGTTACTAATATTATTTTGGCCGCCCTTTTAATGACAATTATTAGTATTTGTAG
TTCATATTTCTTACAAGGTTTAATTGATACTTATATTCCTAATGGCACATATCAAACCTTATCAATTCTAGCCATCGGTT
TATTGATAGCATATGTCTTTAATTCCATCTTTTCTTATGGTCAAAACTTTTTGTTAAATATCTTAGGACAACGATTAAGT
ATTGATCTTAATTTACAATATATTCGCCATATTTTTGAATTACCAATGGAATTTTTTGTGACTCGTAGAACAGGTGAAAT
CACTTCTAGATTCTCTGATGCTAGTCGAATTATTGACGCCTTAGCTAGTACAGTTATTTCATTATTTCTTGACCTTTCAA
TTGTAATTGTAATGGGAATTGTTTTGGCAATTCAAAACTCTACTTTATTCATGATTACTTTGTTAGCACTGCCAGTATAC
GCTGTAGTGATTCTTAGCTTTTCTAAGAAATTTGAAAAGCTGAACAATGATCAGATGGAAAGTAATGCAGTTTTAAGTTC
TTCAGTAATTGAGGATATTCAAGGGATTGAAACGATCAAGGCTTTAAATAGTGAACAGACACGGTACCGTAAGATTGATA
GTCAATTTGTCGATTATCTAAAGAAATCCTTTCGTTACAGTAAAACTGAATCTTTGCAGTCAGCTCTAAAGACTTTCATT
CAACTGTCTCTCAATGTGATTATCCTTTGGGTAGGAGCCAAAGTTGTAATGAACGGTCAGATGAGTATCGGTCAATTAAT
GACATTTAATGCATTGCTATCATATTTTGTAGATCCACTTCAGAGTATTATTAATCTTCAGCCAACCTTACAGTCTGCTA
ATGTAGCTCAAAATCGATTGAATGAAGTATACATGGTTAAGAGCGAGTTTCAGAAAGATGTCCAGATTAGGGATGCAAAG
CAATTAGTAGGAGATATTGAATACCATAATGTAGATTATCATTATGGTTATGGAGTTGATGTTTTAAAGGACGTTAATTT
AAAGATTAAGCAGAATGATAAGTTGGCGATCGTAGGAATGAGTGGCTCAGGCAAGTCAACCATGGTAAAGCTTTTAGTTG
ATTTTTTCTCTCCAAGCAAAGGCAAGTTAACTTTTAATGGATTTGATTCTACTAAAGTAGATAAGCATGTCTTACGGTCA
TACGTAAACTATGTTCCCCAAACACCATACATCTTTTCAGGAACAATCAAAGAAAATCTGCTCTTAGGTAGTCGACCAGA
TATTACAGAAGAAGATGTATTGAAAGCTTGCCAGATAGCAGAGATTGAGTCTGAAATCGAGCAATTACCATTGCAATTTG
AAACTAAGATGGATGAAAATGCCAAGATTTTATCCGGTGGACAAAAGCAAAGGTTAACTATTGCACGTGCATTATTGTCA
CCAGCTAAGGTTTTGATTTTTGATGAAGCCACAAGTGGACTTGATACGATTACGGAGAAAAAAGTAGTAGATAACTTAAT
GAAATTGAAGAATAAAACTATTATTTTTATCGCCCATCGTTTAGCAATTGCGCAAAGGACTAATAATATTGTGGTTGTAG
ACCATGGTCAAATTGTTGAGCAAGGAAGCCATGATGAATTAATGCAAAAACATGGATTCTATTATAACTTAGTTGAAAAT
TAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(502-652)

ABC transporter transmembrane region (ABC_membrane)

(171-440)

Peptidase C39 family (Peptidase_C39)

(9-144)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5FI74

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

56.503

99.306

0.561
  comA Streptococcus pneumoniae Rx1

56.224

99.306

0.558
  comA Streptococcus pneumoniae D39

56.224

99.306

0.558
  comA Streptococcus pneumoniae R6

56.224

99.306

0.558
  comA Streptococcus mitis SK321

56.084

99.306

0.557
  comA Streptococcus pneumoniae TIGR4

56.084

99.306

0.557
  comA Streptococcus gordonii str. Challis substr. CH1

55.804

99.306

0.554
  comA/nlmT Streptococcus mutans UA159

54.096

98.333

0.532