Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SR187_RS08310 Genome accession   NZ_AP018400
Coordinates   1752375..1753097 (-) Length   240 a.a.
NCBI ID   WP_024531872.1    Uniprot ID   A0A2Z5TQ77
Organism   Streptococcus ruminantium strain GUT-187     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1747375..1758097
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS08290 (SR187_8510) - 1748502..1749044 (-) 543 WP_231996434.1 GNAT family N-acetyltransferase -
  SR187_RS08295 (SR187_8515) sufD 1749073..1750335 (-) 1263 WP_120172176.1 Fe-S cluster assembly protein SufD -
  SR187_RS08300 (SR187_8520) sufC 1750352..1751125 (-) 774 WP_024531874.1 Fe-S cluster assembly ATPase SufC -
  SR187_RS08305 (SR187_8525) - 1751218..1752378 (-) 1161 WP_120172178.1 glycosyltransferase family 4 protein -
  SR187_RS08310 (SR187_8530) mecA 1752375..1753097 (-) 723 WP_024531872.1 adaptor protein MecA Regulator
  SR187_RS08315 (SR187_8540) - 1753308..1754144 (-) 837 WP_024531871.1 undecaprenyl-diphosphate phosphatase -
  SR187_RS08320 (SR187_8545) - 1754276..1755838 (+) 1563 WP_120172179.1 ABC transporter substrate-binding protein/permease -
  SR187_RS08325 (SR187_8550) - 1755831..1756574 (+) 744 WP_024531869.1 amino acid ABC transporter ATP-binding protein -
  SR187_RS08330 (SR187_8555) - 1756821..1757030 (-) 210 WP_024531868.1 hypothetical protein -
  SR187_RS09930 (SR187_8560) - 1757116..1758015 (-) 900 WP_024531867.1 SPFH domain-containing protein -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28012.59 Da        Isoelectric Point: 4.1200

>NTDB_id=69463 SR187_RS08310 WP_024531872.1 1752375..1753097(-) (mecA) [Streptococcus ruminantium strain GUT-187]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQNLNFDEFTDLSDLGDVASMTPDEFFKSLEQTVREKSAADVAAVHHLEDIEQAEEDEDGEQERYIYYILEFKKIEELFI
FVGTVDYSIEESELYKMDGYYYLTVLVDIENRSKQYPEHLLSRMLEFSNDTKLARPVLQEHGMLLLSHAAIEELRKVTIA

Nucleotide


Download         Length: 723 bp        

>NTDB_id=69463 SR187_RS08310 WP_024531872.1 1752375..1753097(-) (mecA) [Streptococcus ruminantium strain GUT-187]
ATGAAAGTAAAGCAAATTAGTGATTCTACCTTAAAAATCACTATCAAATTGGATGATTTGGAAGAAAGAGGCATGGAACT
TTCTGACTTTCTTATCCCACAGGAGAAGACAGAAGAGTTTTTCTACACAGTTCTGGATGAGCTGGACTTGCCGATGACTT
TCCGCGAAAGTGGTATGCTGAGTTTCCGTGTGACACCAAAGCCTGATCGGGTTGACATTTTTGTGACCAAATCTGATTTG
GATCAAAATTTGAATTTTGATGAATTTACAGATTTGTCTGACCTTGGTGATGTTGCCAGCATGACTCCAGATGAATTTTT
CAAGAGTTTGGAGCAGACGGTCCGTGAGAAGAGTGCCGCAGATGTAGCTGCTGTCCACCATCTAGAAGATATTGAGCAGG
CAGAAGAGGATGAGGACGGAGAGCAAGAACGGTATATCTACTATATTTTAGAGTTCAAAAAGATTGAAGAACTGTTTATT
TTTGTTGGTACGGTTGACTATTCGATTGAAGAATCGGAACTTTATAAGATGGATGGTTACTATTATCTGACAGTTCTTGT
TGATATAGAAAACCGTTCCAAGCAATATCCAGAGCACCTTCTTTCACGTATGTTAGAGTTTTCCAACGATACAAAATTAG
CAAGACCTGTCTTGCAAGAACACGGGATGCTCCTCCTCTCCCATGCAGCGATTGAAGAGCTTAGAAAGGTTACAATAGCA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TQ77

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

55.328

100

0.563
  mecA Streptococcus pneumoniae D39

55.328

100

0.563
  mecA Streptococcus pneumoniae R6

55.328

100

0.563
  mecA Streptococcus pneumoniae TIGR4

55.328

100

0.563
  mecA Streptococcus mutans UA159

50

100

0.508
  mecA Streptococcus thermophilus LMD-9

46.586

100

0.483
  mecA Streptococcus thermophilus LMG 18311

46.185

100

0.479

Multiple sequence alignment