Detailed information NTG0069359

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: MDRSPN_RS10625
• Genome accession: NZ_AP018391
• Coordinates: 2010782..2011444 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649968.1
• Uniprot ID: A0A098Z9B1
• Organism: Streptococcus pneumoniae strain MDRSPN001
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2005782..2016444

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MDRSPN_RS10600 (MDRSPN_02013)	-	2005932..2006198 (-)	267	WP_001278167.1	Veg family protein	-
MDRSPN_RS10605 (MDRSPN_02014)	dnaB	2006200..2007552 (-)	1353	WP_000852486.1	replicative DNA helicase	-
MDRSPN_RS10610 (MDRSPN_02015)	rplI	2007596..2008048 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
MDRSPN_RS10615 (MDRSPN_02016)	-	2008045..2010018 (-)	1974	WP_000715111.1	DHH family phosphoesterase	-
MDRSPN_RS10620 (MDRSPN_02017)	hpf	2010154..2010702 (-)	549	WP_000599104.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
MDRSPN_RS10625 (MDRSPN_02018)	comFC/cflB	2010782..2011444 (-)	663	WP_000649968.1	ComF family protein	Machinery gene
MDRSPN_RS10630 (MDRSPN_02019)	comFA/cflA	2011441..2012739 (-)	1299	WP_000867608.1	DEAD/DEAH box helicase	Machinery gene
MDRSPN_RS10635 (MDRSPN_02020)	-	2012795..2013430 (+)	636	WP_000395746.1	YigZ family protein	-
MDRSPN_RS10640 (MDRSPN_02021)	cysK	2013715..2014635 (+)	921	WP_000029860.1	cysteine synthase A	-
MDRSPN_RS10650 (MDRSPN_02022)	-	2014710..2015248 (-)	539	Protein_1989	transposase	-
MDRSPN_RS10655 (MDRSPN_02023)	-	2015221..2015529 (+)	309	Protein_1990	transposase	-
MDRSPN_RS10660 (MDRSPN_02024)	tnpB	2015670..2015993 (-)	324	WP_000973416.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25203.05 Da
• Isoelectric Point: 7.7116

>NTDB_id=69359 MDRSPN_RS10625 WP_000649968.1 2010782..2011444(-) (comFC/cflB) [Streptococcus pneumoniae strain MDRSPN001]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=69359 MDRSPN_RS10625 WP_000649968.1 2010782..2011444(-) (comFC/cflB) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAATTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A098Z9B1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae D39	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae R6	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae TIGR4	99.091	100	0.991
comFC/cflB	Streptococcus mitis SK321	91.364	100	0.914
comFC/cflB	Streptococcus mitis NCTC 12261	90.909	100	0.909