Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   MDRSPN_RS04285 Genome accession   NZ_AP018391
Coordinates   821441..822145 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 816441..827145
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS04260 (MDRSPN_00804) coaC 816730..817281 (-) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -
  MDRSPN_RS04265 (MDRSPN_00805) coaB 817293..817982 (-) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  MDRSPN_RS04270 (MDRSPN_00806) - 818212..819882 (+) 1671 WP_120164201.1 formate--tetrahydrofolate ligase -
  MDRSPN_RS04280 (MDRSPN_00807) mutY 820211..821386 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  MDRSPN_RS04285 (MDRSPN_00808) micA 821441..822145 (+) 705 WP_000722076.1 response regulator YycF Regulator
  MDRSPN_RS04290 (MDRSPN_00809) micB 822138..823487 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  MDRSPN_RS04295 (MDRSPN_00810) vicX 823489..824298 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  MDRSPN_RS04300 (MDRSPN_00811) relB 824389..824631 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  MDRSPN_RS04305 (MDRSPN_00812) - 824633..824887 (+) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  MDRSPN_RS04310 (MDRSPN_00813) - 824934..825707 (+) 774 WP_000731129.1 potassium channel family protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=69310 MDRSPN_RS04285 WP_000722076.1 821441..822145(+) (micA) [Streptococcus pneumoniae strain MDRSPN001]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=69310 MDRSPN_RS04285 WP_000722076.1 821441..822145(+) (micA) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment