Detailed information NTG0069308

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: MDRSPN_RS03855
• Genome accession: NZ_AP018391
• Coordinates: 734114..734851 (+)
• Length: 245 a.a.
• NCBI ID: WP_000782676.1
• Uniprot ID: A0A064C3U8
• Organism: Streptococcus pneumoniae strain MDRSPN001
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	732628..733884	734114..734851	flank	230

Gene organization within MGE regions

Location: 732628..734851

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MDRSPN_RS03850 (MDRSPN_00723)	-	732628..733884 (-)	1257	WP_120164197.1	ISL3 family transposase	-
MDRSPN_RS03855 (MDRSPN_00724)	mecA	734114..734851 (+)	738	WP_000782676.1	adaptor protein MecA	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28381.18 Da
• Isoelectric Point: 4.0199

>NTDB_id=69308 MDRSPN_RS03855 WP_000782676.1 734114..734851(+) (mecA) [Streptococcus pneumoniae strain MDRSPN001]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide

• Length: 738 bp

>NTDB_id=69308 MDRSPN_RS03855 WP_000782676.1 734114..734851(+) (mecA) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GATCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTAACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-239)

3D structure

• AlphaFold DB: A0A064C3U8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus pneumoniae Rx1	99.592	100	0.996
mecA	Streptococcus pneumoniae D39	99.592	100	0.996
mecA	Streptococcus pneumoniae R6	99.592	100	0.996
mecA	Streptococcus pneumoniae TIGR4	99.184	100	0.992
mecA	Streptococcus thermophilus LMD-9	47.791	100	0.486
mecA	Streptococcus thermophilus LMG 18311	47.39	100	0.482
mecA	Streptococcus mutans UA159	48.163	100	0.482