Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   MDRSPN_RS00230 Genome accession   NZ_AP018391
Coordinates   42073..43422 (+) Length   449 a.a.
NCBI ID   WP_000801629.1    Uniprot ID   A0A0T8X0V4
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 37073..48422
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS00205 (MDRSPN_00039) plsX 37192..38184 (+) 993 WP_000717456.1 phosphate acyltransferase PlsX -
  MDRSPN_RS00210 (MDRSPN_00040) - 38190..38423 (+) 234 WP_000136447.1 acyl carrier protein -
  MDRSPN_RS00215 (MDRSPN_00041) - 38460..38759 (+) 300 Protein_34 transposase family protein -
  MDRSPN_RS00220 (MDRSPN_00042) blpU 38962..39192 (+) 231 WP_001093071.1 bacteriocin-like peptide BlpU -
  MDRSPN_RS11450 - 39195..39320 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  MDRSPN_RS00225 (MDRSPN_00043) comA 39907..42060 (+) 2154 WP_000668293.1 peptide cleavage/export ABC transporter ComA Regulator
  MDRSPN_RS00230 (MDRSPN_00044) comB 42073..43422 (+) 1350 WP_000801629.1 competence pheromone export protein ComB Regulator
  MDRSPN_RS00235 (MDRSPN_00045) purC 43592..44299 (+) 708 WP_000043313.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  MDRSPN_RS11545 - 44310..44444 (+) 135 WP_000429436.1 hypothetical protein -
  MDRSPN_RS00245 (MDRSPN_00046) - 44501..48226 (+) 3726 WP_000361166.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49525.39 Da        Isoelectric Point: 5.5618

>NTDB_id=69296 MDRSPN_RS00230 WP_000801629.1 42073..43422(+) (comB) [Streptococcus pneumoniae strain MDRSPN001]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQGGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGTLLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=69296 MDRSPN_RS00230 WP_000801629.1 42073..43422(+) (comB) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGGAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGTGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTACCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCTTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
CTTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTAGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T8X0V4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae Rx1

99.332

100

0.993
  comB Streptococcus pneumoniae D39

99.332

100

0.993
  comB Streptococcus pneumoniae R6

99.332

100

0.993
  comB Streptococcus pneumoniae TIGR4

99.109

100

0.991
  comB Streptococcus mitis SK321

95.1

100

0.951
  comB Streptococcus mitis NCTC 12261

94.209

100

0.942
  comB Streptococcus gordonii str. Challis substr. CH1

55.778

100

0.559

Multiple sequence alignment