Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   STO1_RS02225 Genome accession   NZ_AP018338
Coordinates   440979..442859 (+) Length   626 a.a.
NCBI ID   WP_096421770.1    Uniprot ID   A0A224A666
Organism   Streptococcus oralis subsp. tigurinus strain osk_001     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 435979..447859
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STO1_RS02210 (STO1_004340) fmt 437985..438920 (+) 936 WP_096421764.1 methionyl-tRNA formyltransferase -
  STO1_RS02215 (STO1_004350) rsmB 438913..440226 (+) 1314 WP_172843636.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  STO1_RS02220 (STO1_004360) - 440242..440982 (+) 741 WP_096421768.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  STO1_RS02225 (STO1_004370) stkP 440979..442859 (+) 1881 WP_096421770.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  STO1_RS02230 (STO1_004380) - 442945..443703 (+) 759 WP_096421772.1 threonine/serine exporter family protein -
  STO1_RS02235 (STO1_004390) - 443705..444160 (+) 456 WP_000176910.1 threonine/serine exporter family protein -
  STO1_RS02240 (STO1_004400) - 444279..445451 (+) 1173 WP_007520530.1 hydroxymethylglutaryl-CoA synthase -
  STO1_RS02245 (STO1_004410) - 445451..446725 (+) 1275 WP_096421774.1 hydroxymethylglutaryl-CoA reductase, degradative -
  STO1_RS02250 (STO1_004420) - 446761..447726 (-) 966 WP_096421776.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 626 a.a.        Molecular weight: 68276.57 Da        Isoelectric Point: 9.2737

>NTDB_id=69047 STO1_RS02225 WP_096421770.1 440979..442859(+) (stkP) [Streptococcus oralis subsp. tigurinus strain osk_001]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHARGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATFQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVVIKATAKKLSDRYQSVSEMYVDLSTSLSYNRRNEPKLVFDDASKADTKTLPKVPQSTLTSIPKAPAQEERPQLK
KLTPEQAPTQKPTKKRKFKARYMILLASLLLVAASLIWILSRTPATIPIPDVAGQTVAEAKEALKKSKFEAGEEKSEASD
TVAEGRVIRTDPEAGSDRKEGTKVNLIVSSGKKSFQLSNYVGRKYTDVVAELKGKKVPENLIKMEEEESSESEPGTILRQ
SPAAGTTYDLSKASTITLTVAKKVTSVSMPSYIGSSLEFTKNNLTQIVGVKEANIEVVEVSTAPEGTAEGTVVDQTPKAG
EKVDLASTRIKLSIYKPKTPPSTSSSNSAQRGNQSSSSTPNQGNQQGNTPSTSQSNSEGTRESSRD

Nucleotide


Download         Length: 1881 bp        

>NTDB_id=69047 STO1_RS02225 WP_096421770.1 440979..442859(+) (stkP) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGATCCAAATCGGCAAGATTTTTGCCGGGCGGTATCGGATTGTCAAGCAGATTGGTCGAGGAGGCATGGCAGATGTTTA
CTTGGCCAAGGATTTGATCCTAGATGGGGAAGAAGTGGCAGTTAAGGTCCTGAGGACCAACTACCAGACGGACCCGATTG
CTGTGGCACGTTTCCAGCGGGAAGCGAGGGCTATGGCGGATCTGGACCATCCTCATATCGTTCGGATAACAGATATCGGT
GAGGAAGATGGCCAACAGTACCTAGCTATGGAATACGTAGCAGGACTTGACCTCAAGCGGTATATCAAAGAACACTATCC
TCTTTCAAATGAAGAGGCGGTTCGGATTATGGGACAGATTCTTTTGGCTATGCGTTTAGCCCATGCTAGAGGAATTGTTC
ACCGAGATTTGAAACCTCAAAATATCCTCTTGACGCCAGATGGAACTGCTAAAGTTACTGACTTTGGGATTGCAGTGGCC
TTTGCAGAGACGAGTCTGACCCAGACCAACTCGATGCTGGGTTCGGTTCATTATTTGTCACCTGAGCAAGCGCGTGGTTC
AAAAGCGACCTTCCAGAGTGATATCTATGCAATGGGAATTATCTTCTATGAAATGCTGACGGGTCATATCCCTTATGATG
GGGATAGTGCGGTTACGATTGCCCTTCAGCATTTCCAGAAGCCACTTCCGTCCGTCATAGCTGAAAACCCATCTGTCCCT
CAGGCTTTGGAAAATGTTGTCATCAAGGCAACTGCTAAGAAATTGTCTGATCGCTATCAGTCTGTTTCAGAAATGTATGT
GGACTTGTCAACTAGCTTGTCTTATAATCGTCGGAATGAACCGAAACTGGTCTTTGACGATGCGAGTAAGGCGGATACGA
AGACTTTACCTAAAGTCCCACAAAGTACATTGACCTCGATTCCAAAAGCTCCGGCGCAGGAGGAACGTCCTCAGTTAAAG
AAATTAACCCCAGAGCAAGCACCTACGCAAAAGCCAACTAAAAAGCGGAAGTTTAAGGCTCGCTATATGATTCTTTTAGC
TAGTCTTCTGTTGGTTGCGGCCTCTTTAATCTGGATTTTGTCTAGAACACCTGCAACGATTCCCATTCCTGATGTGGCTG
GACAAACCGTTGCAGAGGCTAAAGAAGCACTCAAAAAATCTAAGTTTGAAGCTGGTGAAGAAAAGTCAGAGGCCAGCGAT
ACCGTAGCAGAAGGACGCGTTATTCGAACCGATCCTGAAGCTGGCAGCGACCGAAAAGAAGGAACTAAGGTTAATTTGAT
TGTTTCTTCTGGTAAGAAATCCTTCCAATTGAGTAATTACGTCGGACGCAAGTATACGGATGTCGTAGCTGAACTCAAGG
GGAAGAAGGTTCCTGAGAATCTAATCAAGATGGAAGAGGAGGAATCCAGCGAAAGCGAACCTGGAACCATTCTCAGACAA
AGTCCTGCGGCAGGTACGACTTATGATCTTTCAAAAGCCAGCACAATTACTTTAACGGTTGCTAAGAAAGTAACAAGTGT
TTCTATGCCAAGTTATATTGGTTCAAGTCTCGAATTTACAAAGAATAATTTAACTCAGATTGTCGGTGTAAAAGAGGCCA
ATATTGAGGTTGTCGAAGTTTCGACTGCTCCTGAAGGCACAGCAGAAGGTACAGTTGTAGATCAAACACCAAAAGCGGGT
GAAAAGGTTGACCTTGCTAGCACGCGTATCAAACTTTCCATCTACAAACCGAAAACACCACCGTCAACTTCATCTTCTAA
TTCTGCACAGCGTGGGAACCAAAGTTCTTCTTCAACTCCAAATCAGGGGAACCAACAAGGAAACACTCCTTCAACTAGTC
AATCAAATAGTGAAGGAACGCGTGAAAGTTCTCGAGATTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(507-576)

PASTA domain (PASTA)

(438-502)

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(369-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A224A666

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

72.727

100

0.767
  stkP Streptococcus pneumoniae D39

72.273

100

0.762
  stkP Streptococcus pneumoniae R6

72.273

100

0.762
  stkP Streptococcus pneumoniae Rx1

72.121

100

0.76
  pknB Streptococcus mutans UA159

56.153

92.173

0.518
  stkP/pknB Streptococcus salivarius strain HSISS4

53.504

93.45

0.5

Multiple sequence alignment