Detailed information NTG0690355

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: M8286_RS10010
• Genome accession: NZ_CP097577
• Coordinates: 2073770..2074966 (+)
• Length: 398 a.a.
• NCBI ID: WP_024384306.1
• Uniprot ID: A0A2S2F7U7
• Organism: Streptococcus suis strain 3112
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2068770..2079966

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M8286_RS09980 (M8286_10130)	-	2069427..2072006 (+)	2580	WP_275601110.1	YfhO family protein	-
M8286_RS10000 (M8286_10150)	-	2072409..2073092 (-)	684	WP_029171250.1	YoaK family protein	-
M8286_RS10005 (M8286_10155)	rlmH	2073117..2073596 (-)	480	WP_004194528.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
M8286_RS10010 (M8286_10160)	htrA	2073770..2074966 (+)	1197	WP_024384306.1	trypsin-like peptidase domain-containing protein	Regulator
M8286_RS10015 (M8286_10165)	spo0J	2075027..2075791 (+)	765	WP_275601112.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41866.89 Da
• Isoelectric Point: 4.4971

>NTDB_id=690355 M8286_RS10010 WP_024384306.1 2073770..2074966(+) (htrA) [Streptococcus suis strain 3112]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTTVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSEDGQTISTNAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKITSSSVSSSGVAVEGMGFAIPANDAVAIINQLEKDGKVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=690355 M8286_RS10010 WP_024384306.1 2073770..2074966(+) (htrA) [Streptococcus suis strain 3112]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTCTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAACCACAGGTTCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTGCAAAATGCTGTTGTGTCCGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATTCTTT
TAGCATCTGGAGAAAAAATCAGCGGTGAACTCGTTGGTTCAGATACCTATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTACTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGTGTCTACGCCAATACAGTTACTCAAGGTATTATTTCCAGCCTAAGTCGGACAGTTACTTCACAATCAGAAG
ACGGACAAACAATCTCAACCAATGCTATTCAAACCGATACAGCTATCAACCCAGGAAACTCTGGAGGACCATTGATTAAT
ATCCAAGGACAAGTTATTGGTATCACCTCTAGCAAAATCACCTCAAGTTCGGTAAGTAGCTCTGGTGTGGCTGTGGAAGG
GATGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAACTTGAAAAAGATGGAAAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTGGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (293-389)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A2S2F7U7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	60.705	99.749	0.606
htrA	Streptococcus gordonii str. Challis substr. CH1	60.506	99.246	0.6
htrA	Streptococcus pneumoniae D39	57.761	98.744	0.57
htrA	Streptococcus pneumoniae TIGR4	57.761	98.744	0.57
htrA	Streptococcus mitis NCTC 12261	57.761	98.744	0.57
htrA	Streptococcus pneumoniae R6	57.761	98.744	0.57
htrA	Streptococcus pneumoniae Rx1	57.761	98.744	0.57