Detailed information NTG0068669

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: KK0981_RS02640
• Genome accession: NZ_AP017971
• Coordinates: 489096..489833 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219145.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain KK0981
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 484096..494833

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KK0981_RS11925 (KK0981_25190)	-	485027..485266 (-)	240	WP_001813906.1	hypothetical protein	-
KK0981_RS02610 (KK0981_25200)	-	485428..485715 (-)	288	WP_000777760.1	hypothetical protein	-
KK0981_RS02615 (KK0981_25210)	-	485725..486135 (-)	411	WP_001278301.1	HIT family protein	-
KK0981_RS02620 (KK0981_25220)	pptA	486203..486934 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
KK0981_RS02625 (KK0981_25230)	-	486931..487980 (+)	1050	WP_000653771.1	ABC transporter permease	-
KK0981_RS02630 (KK0981_25240)	-	488148..488477 (-)	330	WP_000132572.1	hypothetical protein	-
KK0981_RS02635 (KK0981_25250)	-	488753..489091 (+)	339	WP_000682118.1	LytTR family DNA-binding domain-containing protein	-
KK0981_RS02640 (KK0981_25260)	comE/blpR	489096..489833 (+)	738	WP_001219145.1	response regulator transcription factor	Regulator
KK0981_RS02645 (KK0981_25270)	-	489847..491187 (+)	1341	WP_001017624.1	sensor histidine kinase	-
KK0981_RS02650 (KK0981_25280)	blpC	491229..491384 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
KK0981_RS02655 (KK0981_25290)	-	491441..492802 (-)	1362	WP_001069090.1	bacteriocin secretion accessory protein	-
KK0981_RS02660 (KK0981_25300)	comA/nlmT	492813..494489 (-)	1677	WP_319014187.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28798.90 Da
• Isoelectric Point: 6.0454

>NTDB_id=68669 KK0981_RS02640 WP_001219145.1 489096..489833(+) (comE/blpR) [Streptococcus pneumoniae strain KK0981]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=68669 KK0981_RS02640 WP_001219145.1 489096..489833(+) (comE/blpR) [Streptococcus pneumoniae strain KK0981]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363