Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   M2914_RS11925 Genome accession   NZ_CP097031
Coordinates   2479691..2480989 (+) Length   432 a.a.
NCBI ID   WP_116495166.1    Uniprot ID   -
Organism   Enterococcus faecalis strain AT41     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2474691..2485989
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M2914_RS11900 (M2914_11900) - 2474974..2475438 (-) 465 WP_002355030.1 sigma-70 family RNA polymerase sigma factor -
  M2914_RS11905 (M2914_11905) gst 2475578..2476087 (-) 510 WP_002370068.1 DinB family glutathione transferase -
  M2914_RS11910 (M2914_11910) - 2476420..2477823 (+) 1404 WP_002383291.1 dicarboxylate/amino acid:cation symporter -
  M2914_RS11915 (M2914_11915) - 2477921..2478763 (-) 843 WP_116495167.1 hypothetical protein -
  M2914_RS11920 (M2914_11920) rlmH 2478811..2479290 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M2914_RS11925 (M2914_11925) htrA 2479691..2480989 (+) 1299 WP_116495166.1 trypsin-like peptidase domain-containing protein Regulator
  M2914_RS11930 (M2914_11930) ytpR 2481036..2481656 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  M2914_RS11935 (M2914_11935) - 2481867..2482322 (-) 456 WP_002385249.1 universal stress protein -
  M2914_RS11940 (M2914_11940) - 2482470..2482784 (-) 315 WP_116495165.1 thioredoxin family protein -
  M2914_RS11945 (M2914_11945) pepA 2482796..2483872 (-) 1077 WP_002355013.1 glutamyl aminopeptidase -
  M2914_RS11950 (M2914_11950) - 2484179..2484520 (+) 342 WP_002355012.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44861.98 Da        Isoelectric Point: 4.9968

>NTDB_id=686418 M2914_RS11925 WP_116495166.1 2479691..2480989(+) (htrA) [Enterococcus faecalis strain AT41]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNESTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=686418 M2914_RS11925 WP_116495166.1 2479691..2480989(+) (htrA) [Enterococcus faecalis strain AT41]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCATGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAAGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTGGATAAAGCACAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAGTTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCGATTGCGATTG
GTTCCCCTCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCTATTAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGTGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGCATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGTCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.791

84.259

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456