Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   M2917_RS01175 Genome accession   NZ_CP097022
Coordinates   234992..236278 (-) Length   428 a.a.
NCBI ID   WP_002325236.1    Uniprot ID   A0A366TVN3
Organism   Enterococcus faecium strain AT45b     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 229992..241278
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M2917_RS01145 (M2917_01145) - 230395..231342 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  M2917_RS01150 (M2917_01150) - 231565..231915 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  M2917_RS01155 (M2917_01155) pepA 232115..233194 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  M2917_RS01160 (M2917_01160) - 233337..233657 (+) 321 WP_002287837.1 thioredoxin family protein -
  M2917_RS01165 (M2917_01165) - 233679..234143 (+) 465 WP_002287838.1 universal stress protein -
  M2917_RS01170 (M2917_01170) ytpR 234348..234953 (+) 606 WP_002328066.1 YtpR family tRNA-binding protein -
  M2917_RS01175 (M2917_01175) htrA 234992..236278 (-) 1287 WP_002325236.1 trypsin-like peptidase domain-containing protein Regulator
  M2917_RS01180 (M2917_01180) rlmH 236706..237185 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M2917_RS01185 (M2917_01185) - 237508..239148 (+) 1641 WP_002328333.1 hypothetical protein -
  M2917_RS01190 (M2917_01190) - 239471..239716 (+) 246 WP_025478958.1 hypothetical protein -
  M2917_RS01195 (M2917_01195) - 240021..240581 (-) 561 WP_002294749.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.81 Da        Isoelectric Point: 4.5419

>NTDB_id=686282 M2917_RS01175 WP_002325236.1 234992..236278(-) (htrA) [Enterococcus faecium strain AT45b]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=686282 M2917_RS01175 WP_002325236.1 234992..236278(-) (htrA) [Enterococcus faecium strain AT45b]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGCCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A366TVN3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465