Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   M2920_RS01130 Genome accession   NZ_CP097014
Coordinates   226709..227995 (-) Length   428 a.a.
NCBI ID   WP_002325236.1    Uniprot ID   A0A366TVN3
Organism   Enterococcus faecium strain AT47b     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 221709..232995
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M2920_RS01100 (M2920_01100) - 222112..223059 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  M2920_RS01105 (M2920_01105) - 223282..223632 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  M2920_RS01110 (M2920_01110) pepA 223832..224911 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  M2920_RS01115 (M2920_01115) - 225054..225374 (+) 321 WP_002287837.1 thioredoxin family protein -
  M2920_RS01120 (M2920_01120) - 225396..225860 (+) 465 WP_002287838.1 universal stress protein -
  M2920_RS01125 (M2920_01125) ytpR 226065..226670 (+) 606 WP_010717984.1 YtpR family tRNA-binding protein -
  M2920_RS01130 (M2920_01130) htrA 226709..227995 (-) 1287 WP_002325236.1 trypsin-like peptidase domain-containing protein Regulator
  M2920_RS01135 (M2920_01135) rlmH 228423..228902 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M2920_RS01140 (M2920_01140) - 229159..230337 (-) 1179 WP_002328152.1 IS256-like element ISEfm2 family transposase -
  M2920_RS01145 (M2920_01145) - 230606..231127 (+) 522 WP_225587545.1 hypothetical protein -
  M2920_RS01150 (M2920_01150) - 231243..231563 (+) 321 Protein_229 recombinase family protein -
  M2920_RS01155 (M2920_01155) - 231741..232802 (+) 1062 Protein_230 class I SAM-dependent DNA methyltransferase -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.81 Da        Isoelectric Point: 4.5419

>NTDB_id=686174 M2920_RS01130 WP_002325236.1 226709..227995(-) (htrA) [Enterococcus faecium strain AT47b]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=686174 M2920_RS01130 WP_002325236.1 226709..227995(-) (htrA) [Enterococcus faecium strain AT47b]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGCCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGTGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A366TVN3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465