Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   M2923_RS11405 Genome accession   NZ_CP097008
Coordinates   2419349..2420647 (+) Length   432 a.a.
NCBI ID   WP_346429111.1    Uniprot ID   -
Organism   Enterococcus faecalis strain AT50     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2414349..2425647
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M2923_RS11390 (M2923_11390) - 2414950..2417217 (-) 2268 WP_010709933.1 TIM-barrel domain-containing protein -
  M2923_RS11395 (M2923_11395) - 2417219..2418226 (-) 1008 WP_002359092.1 LacI family DNA-binding transcriptional regulator -
  M2923_RS11400 (M2923_11400) rlmH 2418469..2418948 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M2923_RS11405 (M2923_11405) htrA 2419349..2420647 (+) 1299 WP_346429111.1 trypsin-like peptidase domain-containing protein Regulator
  M2923_RS11410 (M2923_11410) ytpR 2420694..2421314 (-) 621 WP_248857844.1 YtpR family tRNA-binding protein -
  M2923_RS11415 (M2923_11415) - 2421525..2421980 (-) 456 WP_002385249.1 universal stress protein -
  M2923_RS11420 (M2923_11420) - 2422128..2422442 (-) 315 WP_002355015.1 thioredoxin family protein -
  M2923_RS11425 (M2923_11425) pepA 2422454..2423530 (-) 1077 WP_002355013.1 glutamyl aminopeptidase -
  M2923_RS11430 (M2923_11430) - 2423837..2424178 (+) 342 WP_002355012.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44818.95 Da        Isoelectric Point: 4.9968

>NTDB_id=686128 M2923_RS11405 WP_346429111.1 2419349..2420647(+) (htrA) [Enterococcus faecalis strain AT50]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITSK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDISSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=686128 M2923_RS11405 WP_346429111.1 2419349..2420647(+) (htrA) [Enterococcus faecalis strain AT50]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCTCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTTGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGAAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCTCTAGGCTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAGTAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCCATCAATCCAGGAAACTCCGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGCATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGCGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACATAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(9-416)

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.659

94.907

0.509
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.405

85.648

0.475
  htrA Streptococcus pneumoniae TIGR4

56.091

81.713

0.458
  htrA Streptococcus pneumoniae Rx1

56.091

81.713

0.458
  htrA Streptococcus pneumoniae D39

56.091

81.713

0.458
  htrA Streptococcus pneumoniae R6

56.091

81.713

0.458