Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   M2925_RS11435 Genome accession   NZ_CP097004
Coordinates   2409283..2410572 (+) Length   429 a.a.
NCBI ID   WP_002416060.1    Uniprot ID   A0AAV3GJE7
Organism   Enterococcus faecalis strain LS05-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2404283..2415572
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M2925_RS11410 (M2925_11410) - 2404571..2405035 (-) 465 WP_002383292.1 sigma-70 family RNA polymerase sigma factor -
  M2925_RS11415 (M2925_11415) gst 2405174..2405683 (-) 510 WP_219259751.1 DinB family protein -
  M2925_RS11420 (M2925_11420) - 2406012..2407415 (+) 1404 WP_002387350.1 dicarboxylate/amino acid:cation symporter -
  M2925_RS11425 (M2925_11425) - 2407513..2408355 (-) 843 WP_002381116.1 hypothetical protein -
  M2925_RS11430 (M2925_11430) rlmH 2408403..2408882 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  M2925_RS11435 (M2925_11435) htrA 2409283..2410572 (+) 1290 WP_002416060.1 trypsin-like peptidase domain-containing protein Regulator
  M2925_RS11440 (M2925_11440) - 2410879..2411484 (-) 606 WP_002383287.1 ABC transporter ATP-binding protein -
  M2925_RS11445 (M2925_11445) - 2411481..2413496 (-) 2016 WP_002383286.1 hypothetical protein -
  M2925_RS11450 (M2925_11450) - 2413584..2413910 (-) 327 WP_010715459.1 hypothetical protein -
  M2925_RS11455 (M2925_11455) ytpR 2414246..2414866 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  M2925_RS11460 (M2925_11460) - 2415077..2415532 (-) 456 WP_002385249.1 universal stress protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44502.68 Da        Isoelectric Point: 5.1271

>NTDB_id=686056 M2925_RS11435 WP_002416060.1 2409283..2410572(+) (htrA) [Enterococcus faecalis strain LS05-2]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQKQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNR

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=686056 M2925_RS11435 WP_002416060.1 2409283..2410572(+) (htrA) [Enterococcus faecalis strain LS05-2]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACGTCCACTAATCACGGTGATACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCACAAGGATTGGAA
GTTGTTTTGTCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTATACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCTCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAATCCGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCCATCAATCCAGGAAACTCCGGTGGTCCACT
AATCAATATTGAAGGGCAAGTCATTGGCATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACACGGCCAGCT
CTTGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAAAAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAAGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

95.571

0.508
  htrA Streptococcus mutans UA159

58.63

85.082

0.499
  htrA Streptococcus mitis NCTC 12261

55.135

86.247

0.476
  htrA Streptococcus pneumoniae TIGR4

55.807

82.284

0.459
  htrA Streptococcus pneumoniae Rx1

55.807

82.284

0.459
  htrA Streptococcus pneumoniae D39

55.807

82.284

0.459
  htrA Streptococcus pneumoniae R6

55.807

82.284

0.459