Detailed information NTG0068355

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SNAG_RS06260
• Genome accession: NZ_AP017652
• Coordinates: 1200651..1202891 (-)
• Length: 746 a.a.
• NCBI ID: WP_096407597.1
• Uniprot ID: A0A1E1GBK0
• Organism: Streptococcus sp. NPS 308
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1195651..1207891

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SNAG_RS06230 (SNAG_1218)	-	1195825..1196625 (-)	801	WP_096407590.1	dihydroorotate dehydrogenase electron transfer subunit	-
SNAG_RS06235 (SNAG_1219)	-	1196873..1198294 (-)	1422	WP_157740121.1	hypothetical protein	-
SNAG_RS06240 (SNAG_1220)	-	1198817..1199197 (-)	381	WP_096407595.1	VOC family protein	-
SNAG_RS06245 (SNAG_1221)	rplT	1199256..1199615 (-)	360	WP_000124832.1	50S ribosomal protein L20	-
SNAG_RS06250 (SNAG_1222)	rpmI	1199667..1199867 (-)	201	WP_001125942.1	50S ribosomal protein L35	-
SNAG_RS06255 (SNAG_1223)	infC	1199900..1200430 (-)	531	WP_000848184.1	translation initiation factor IF-3	-
SNAG_RS06260 (SNAG_1224)	comEC/celB	1200651..1202891 (-)	2241	WP_096407597.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SNAG_RS06265 (SNAG_1225)	comEA/celA/cilE	1202875..1203525 (-)	651	WP_096407600.1	helix-hairpin-helix domain-containing protein	Machinery gene
SNAG_RS06270 (SNAG_1226)	-	1203592..1204161 (-)	570	WP_096407603.1	GNAT family N-acetyltransferase	-
SNAG_RS06275 (SNAG_1227)	ald	1204341..1205453 (+)	1113	WP_096407605.1	alanine dehydrogenase	-
SNAG_RS06280 (SNAG_1228)	-	1205504..1206490 (-)	987	WP_049550008.1	PhoH family protein	-
SNAG_RS06285 (SNAG_1229)	-	1206571..1206786 (-)	216	WP_001232084.1	YozE family protein	-
SNAG_RS06290 (SNAG_1230)	-	1206783..1207388 (-)	606	WP_096407608.1	GrpB family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84811.12 Da
• Isoelectric Point: 9.4574

>NTDB_id=68355 SNAG_RS06260 WP_096407597.1 1200651..1202891(-) (comEC/celB) [Streptococcus sp. NPS 308]
MLRWIKNFPIPLIYLSFLLLWLYYAIFSVSYLALLGFVFLLVCLFIQFPWKSAGKVLAICGFFGFWFLFQNWQQTQASQD
LVASVEKVRILPDTIKVNGDSLSFRGKTDGRTFQVYYKLQSEEEKEQFQALTELYEIELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLTIKSIQSMKKISSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLFGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLIYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLIISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFILSFVYPVTQLNLAFEWLESIIHLVSQMASRPLVFGQPNAWLLILLLVSLALVYDFRKNVKRLAGFSLFIVGFFFLTK
HPLENEITMLDVGQGESIFLRDVTGKNILIDVGGKAESDKKIQAWQQKSTTSNAKRTLIPYLKSRGVDKIDQLILTNTDK
EHVGDLLEVTNAFHVGEILVSKGSLTQKEFVAELQATQTKVRSVTAGENLPIFGNQLEVLSTRQIGDGNRNDSLLLYGKL
LDKHFLFTGNLKERGEQELLKQYPTIEVDILKAGQHGSKISSSPAFLEKLKPEITLISVGKNNRAKLPHQETLARLESIK
SKIYRTDQQGAIRFKGWNSWRMETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=68355 SNAG_RS06260 WP_096407597.1 1200651..1202891(-) (comEC/celB) [Streptococcus sp. NPS 308]
ATGTTACGGTGGATTAAGAACTTCCCTATCCCCCTAATCTATCTGAGTTTTCTGTTGCTTTGGCTTTACTACGCCATTTT
CTCCGTATCTTATCTCGCGCTGCTAGGTTTCGTTTTTCTGCTAGTTTGTCTCTTTATCCAATTTCCTTGGAAATCGGCTG
GTAAAGTTTTAGCGATTTGTGGATTTTTTGGATTTTGGTTTCTGTTTCAAAACTGGCAACAGACACAAGCTAGTCAAGAC
TTAGTTGCGTCTGTAGAGAAGGTGAGAATTTTACCAGATACTATTAAGGTTAATGGAGATAGTCTATCTTTTCGGGGCAA
GACTGACGGACGTACTTTCCAAGTTTACTATAAACTCCAGTCCGAGGAGGAGAAAGAGCAATTTCAAGCCTTGACAGAGC
TCTATGAGATAGAACTAGAAGGAAAACTTTCGGAACCAGAAGGCCAGAGGAATTTTGGTGGCTTTGACTACCAAGCCTAT
CTGAAAACTCAGGGGATTTACCAAACTTTGACTATCAAGAGTATCCAGTCAATGAAAAAGATTAGCAGTTGGGATATAGG
AGAAAATCTGTCCAGTTTACGTCGAAAGGCTGTAGTTTGGATCAAGACGCACTTTCCCGACCCTATGCGCAACTATATGA
CAGGTCTTCTTTTTGGACATCTGGATACGGACTTCGAGGAGATGAATGAGCTTTATTCCAGTCTAGGGATTATCCATCTC
TTTGCCTTGTCGGGTATGCAGGTTGGATTTTTTATGGATGGGTTTAAGAAGCTCCTTTTGCGATTGGGCTTGACTCAAGA
AAAGTTGAAGTGGCTGATCTACCCTTTTTCCCTTATCTATGCAGGTCTGACAGGGTTCTCAGCTTCGGTCATTCGTAGTC
TCTTACAAAAATTACTAGCCCAACATGGTGTTAAGGGCTTGGACAATTTTGCCTTAACGGTTCTTGTCCTCTTTATCATC
ATGCCCAACTTTTTCCTGACAGCAGGAGGTGTCTTGTCCTGTGCCTACGCTTTTATCTTGACTATGACAAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCCAGAGAAAGTCTGATAATTTCCTTGGGAATATTGCCCATTTTGTCCTTTTATTTTGCAG
AATTTCAGCCTTGGTCAATCCTTTTGACCTTTGTCTTTTCCTTCTTGTTTGACTTGGTTTTCTTACCGCTTTTGTCTATC
TTATTCATTCTGTCTTTTGTTTACCCAGTCACTCAGCTTAACCTTGCCTTTGAATGGTTAGAGAGCATCATTCACTTGGT
ATCGCAGATGGCAAGTAGGCCCTTGGTCTTTGGCCAACCCAACGCATGGCTTTTGATTCTTCTCTTAGTTTCATTGGCCT
TGGTCTATGACTTTAGGAAAAATGTCAAAAGACTAGCAGGATTCAGCCTCTTTATCGTAGGGTTCTTTTTCTTAACCAAA
CACCCGCTGGAAAATGAAATTACCATGCTGGATGTAGGGCAGGGAGAAAGTATTTTTCTAAGGGATGTAACTGGTAAAAA
CATTCTCATAGATGTGGGCGGAAAGGCAGAATCCGACAAAAAAATCCAAGCTTGGCAGCAAAAGTCGACAACCAGCAATG
CCAAGAGAACCTTGATTCCCTATCTGAAAAGTCGAGGAGTAGATAAGATTGATCAGCTGATTTTGACCAATACAGACAAG
GAGCATGTTGGAGATTTGCTGGAGGTGACCAATGCTTTCCATGTGGGCGAAATTTTAGTGTCAAAAGGAAGTTTGACACA
GAAGGAATTTGTGGCAGAACTACAAGCGACTCAAACCAAGGTACGCAGTGTAACTGCAGGGGAGAACTTGCCGATTTTTG
GGAATCAGTTAGAAGTCCTATCTACAAGGCAGATTGGAGATGGGAATCGTAATGATTCTCTCCTTCTTTATGGAAAACTC
TTGGATAAGCACTTTCTCTTTACTGGGAATTTGAAGGAGAGGGGAGAGCAGGAACTTTTAAAGCAATACCCTACCATAGA
GGTGGATATCTTGAAAGCAGGTCAACATGGTTCAAAGATTTCATCTAGTCCAGCTTTTTTAGAGAAGCTCAAACCGGAAA
TTACTCTTATTTCAGTGGGCAAGAACAATCGTGCCAAACTCCCTCATCAGGAAACCTTGGCACGACTAGAAAGCATCAAG
AGTAAGATTTACCGAACAGACCAGCAAGGAGCCATTCGCTTTAAAGGTTGGAATAGTTGGCGAATGGAAACAGTGCGATA
A

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-457)

• Domain of unknown function (DUF4131) (DUF4131) (29-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-637)

3D structure

• AlphaFold DB: A0A1E1GBK0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis NCTC 12261	88.054	99.866	0.879
comEC/celB	Streptococcus mitis SK321	87.668	100	0.877
comEC/celB	Streptococcus pneumoniae TIGR4	86.059	100	0.861
comEC/celB	Streptococcus pneumoniae Rx1	85.523	100	0.855
comEC/celB	Streptococcus pneumoniae D39	85.523	100	0.855
comEC/celB	Streptococcus pneumoniae R6	85.523	100	0.855
comEC	Lactococcus lactis subsp. cremoris KW2	45.074	99.33	0.448