Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   MO978_RS00455 Genome accession   NZ_CP093959
Coordinates   80091..82238 (+) Length   715 a.a.
NCBI ID   WP_373961939.1    Uniprot ID   -
Organism   Lactococcus lactis strain FAM 17919     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 76228..103960 80091..82238 within 0


Gene organization within MGE regions


Location: 76228..103960
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MO978_RS00430 (MO978_00430) - 76228..76695 (+) 468 WP_010905090.1 universal stress protein -
  MO978_RS00435 (MO978_00435) - 76824..77021 (+) 198 WP_010905091.1 DUF4649 domain-containing protein -
  MO978_RS00440 (MO978_00440) - 77052..77672 (+) 621 WP_023163569.1 alpha/beta hydrolase -
  MO978_RS00445 (MO978_00445) - 77723..78892 (+) 1170 WP_289424726.1 ring-cleaving dioxygenase -
  MO978_RS00450 (MO978_00450) - 78903..79493 (+) 591 WP_003132255.1 flavin reductase family protein -
  MO978_RS00455 (MO978_00455) comA 80091..82238 (+) 2148 WP_373961939.1 peptide cleavage/export ABC transporter Regulator
  MO978_RS00460 (MO978_00460) - 82253..83674 (+) 1422 WP_010905095.1 HlyD family secretion protein -
  MO978_RS00465 (MO978_00465) - 83768..83905 (+) 138 WP_021214958.1 lactococcin family bacteriocin -
  MO978_RS00470 (MO978_00470) - 83920..84630 (+) 711 WP_063283332.1 CPBP family intramembrane glutamic endopeptidase -
  MO978_RS00475 (MO978_00475) - 85056..85508 (+) 453 WP_010905102.1 transporter -
  MO978_RS00480 (MO978_00480) - 85719..86381 (-) 663 WP_021214959.1 CPBP family intramembrane glutamic endopeptidase -
  MO978_RS00490 (MO978_00490) - 87829..88197 (+) 369 WP_010905106.1 hypothetical protein -
  MO978_RS00495 (MO978_00495) - 88417..88719 (-) 303 WP_003132256.1 hypothetical protein -
  MO978_RS00500 (MO978_00500) - 88721..88888 (-) 168 WP_003132257.1 lactococcin family bacteriocin -
  MO978_RS00505 (MO978_00505) rpmG 89455..89604 (-) 150 WP_003132258.1 50S ribosomal protein L33 -
  MO978_RS00510 (MO978_00510) rpmF 89634..89807 (-) 174 WP_010905107.1 50S ribosomal protein L32 -
  MO978_RS00515 (MO978_00515) - 90171..91952 (+) 1782 WP_127094094.1 heavy metal translocating P-type ATPase -
  MO978_RS00520 (MO978_00520) - 92004..92789 (-) 786 WP_010905109.1 ParB/RepB/Spo0J family partition protein -
  MO978_RS00525 (MO978_00525) - 92844..94103 (-) 1260 WP_010905110.1 replication-associated recombination protein A -
  MO978_RS00530 (MO978_00530) - 94147..94635 (-) 489 WP_012896945.1 GNAT family N-acetyltransferase -
  MO978_RS00535 (MO978_00535) - 94787..95254 (+) 468 WP_010905112.1 DUF3013 family protein -
  MO978_RS00540 (MO978_00540) - 95284..96837 (+) 1554 WP_010905113.1 ABC-F family ATP-binding cassette domain-containing protein -
  MO978_RS00545 (MO978_00545) - 96968..97252 (+) 285 WP_010905114.1 hypothetical protein -
  MO978_RS00550 (MO978_00550) - 97290..97778 (+) 489 WP_010905115.1 YdeI/OmpD-associated family protein -
  MO978_RS00555 (MO978_00555) prmA 97796..98749 (+) 954 WP_010905116.1 50S ribosomal protein L11 methyltransferase -
  MO978_RS00560 (MO978_00560) - 98849..99601 (+) 753 WP_010905117.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  MO978_RS00565 (MO978_00565) - 99630..100586 (+) 957 WP_010905118.1 polysaccharide deacetylase family protein -
  MO978_RS00570 (MO978_00570) - 100787..103009 (+) 2223 WP_010905119.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
  MO978_RS00575 (MO978_00575) - 103025..103960 (-) 936 WP_003132278.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 715 a.a.        Molecular weight: 79797.34 Da        Isoelectric Point: 8.3027

>NTDB_id=665918 MO978_RS00455 WP_373961939.1 80091..82238(+) (comA) [Lactococcus lactis strain FAM 17919]
MKFKKKNYTSQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLGFVVQVLRADASLFEMKKV
PYPFIAHVIKNQKYPHYYVITGANKNSVFIADPDPSVKMTKLSKEVFLSEWTGISLFLSPTPSYQPTKEKTSSLLSFIPI
ITRQKKVILNIVIASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKAFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVLMTGLILGLQNMQLFLLVLLAIPLYIV
VIIIFTPLFERQNHEVMQTNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKEAFTLQQSEAIQTAIKTTVQL
VLNVLILWFGATLVMHQKITLGQLITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLSHF
NLNMSEISYQYGFGRKVLSGIELSIKENEKLTIVGMSGSGKSTLVKLLVNFFQPTSGTITLGGIDLQQLDKHQLRRLINY
LPQQPYIFSGSIMENLLLGANESTSQEEMIKAVELAEIRADIEQMQLGYQTELSSDASSLSGGQKQRIALARALLSPAKI
LILDEATSNLDMITEKKILKNLLALDKTIIFIAHRLSVAEMSHRIIVIEQGKVIESGSHSELLAQNGFYAQLYHN

Nucleotide


Download         Length: 2148 bp        

>NTDB_id=665918 MO978_RS00455 WP_373961939.1 80091..82238(+) (comA) [Lactococcus lactis strain FAM 17919]
ATGAAATTTAAAAAGAAAAATTATACCTCCCAAGTAGATGAAATGGATTGTGGATGTGCTGCTTTATCAATGATTTTAAA
ATCCTATGGGACAGAAAAATCGCTTGCCTCTCTTCGTTTACTTGCTGGTACAACAATCGAGGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGTTTAGGTTTTGTAGTTCAAGTACTAAGAGCTGATGCAAGCCTTTTTGAAATGAAGAAAGTC
CCTTACCCTTTTATTGCTCATGTCATCAAGAACCAAAAGTATCCACACTACTATGTGATAACTGGCGCAAATAAAAATTC
GGTATTCATTGCGGATCCTGACCCGTCCGTTAAAATGACAAAACTTTCAAAAGAAGTTTTCTTATCAGAGTGGACAGGCA
TTAGCTTATTTCTTTCACCTACCCCATCCTATCAGCCCACTAAAGAAAAAACTTCTTCATTATTATCTTTTATCCCAATT
ATCACCCGTCAAAAGAAAGTCATTCTCAATATTGTAATTGCCTCATTCATTGTAACGTTGATTAATATTCTAGGGTCTTA
CTACCTCCAGAGCATGATTGATAGTTACATTCCAAATGCCTTAATGGGAACTTTAGGGATTATCTCAGTAGGGCTATTGT
TAACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGGCTTTCTTACTAAACGTTCTTTCTCAAAGATTAGCCATTGAT
GTCATCCTTTCCTATATTAGACACATTTTCCAACTCCCGATGTCTTTCTTTTCGACTAGAAGAACAGGGGAAATTACCAG
TCGGTTTTCCGATGCCAGTTCTATTTTGGATGCTATTGCCTCAACGATTCTTTCGCTCTTTTTAGATTTAACCATTGTTC
TTATGACAGGACTGATTTTAGGGCTTCAAAATATGCAACTCTTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACTCCGCTTTTTGAAAGACAAAATCATGAAGTTATGCAAACCAATGCCATCTTAAATTCCTCAAT
TATTGAAGACATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAGAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAGAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGCAATAAAAACGACAGTACAACTT
GTACTAAATGTTCTTATTTTATGGTTTGGTGCAACTTTAGTCATGCATCAAAAAATTACCCTCGGACAACTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTACAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAAGAAAAGAAAACAGAACTGTCCCTCTCACATTTT
AATTTAAACATGTCTGAAATTTCATATCAATATGGCTTTGGCAGAAAGGTCTTATCTGGGATAGAACTCTCTATCAAAGA
AAATGAAAAGTTGACCATTGTTGGTATGAGTGGTTCAGGAAAAAGTACCCTTGTTAAATTACTCGTCAACTTCTTTCAAC
CGACTTCTGGCACCATCACTTTAGGTGGAATTGACCTCCAACAACTTGATAAACATCAACTCCGAAGATTAATCAATTAT
CTTCCCCAACAACCTTATATTTTCTCTGGTTCGATTATGGAAAATTTACTTTTAGGCGCAAATGAATCGACTTCACAAGA
AGAGATGATTAAAGCGGTGGAATTAGCAGAAATTCGTGCAGATATTGAACAAATGCAATTAGGTTATCAAACCGAGCTCT
CAAGTGATGCAAGTAGTCTATCGGGAGGACAAAAACAACGAATTGCTTTAGCTCGTGCGCTCCTTTCTCCTGCCAAAATA
CTCATTTTAGATGAAGCCACCAGTAATCTTGATATGATTACTGAAAAGAAAATATTAAAGAATTTGTTGGCACTAGATAA
GACAATTATTTTCATTGCTCACCGCCTCTCTGTAGCGGAAATGAGCCATCGTATCATTGTCATTGAACAAGGAAAAGTGA
TAGAAAGTGGTTCACATTCAGAACTGCTTGCTCAAAATGGCTTTTACGCACAACTTTACCATAACTAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-437)

ABC transporter (ABC_tran)

(498-648)

Peptidase C39 family (Peptidase_C39)

(6-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus gordonii str. Challis substr. CH1

61.064

99.86

0.61
  comA Streptococcus mitis SK321

59.804

99.86

0.597
  comA Streptococcus mitis NCTC 12261

59.664

99.86

0.596
  comA Streptococcus pneumoniae R6

59.524

99.86

0.594
  comA Streptococcus pneumoniae Rx1

59.524

99.86

0.594
  comA Streptococcus pneumoniae D39

59.524

99.86

0.594
  comA Streptococcus pneumoniae TIGR4

59.244

99.86

0.592
  comA/nlmT Streptococcus mutans UA159

58.635

100

0.589