Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   MOW07_RS06770 Genome accession   NZ_CP093926
Coordinates   1421368..1422654 (+) Length   428 a.a.
NCBI ID   WP_088774953.1    Uniprot ID   -
Organism   Enterococcus hirae strain GDIAS-5     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1372442..1420915 1421368..1422654 flank 453


Gene organization within MGE regions


Location: 1372442..1422654
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MOW07_RS06525 (MOW07_06530) - 1372442..1373604 (+) 1163 WP_167844242.1 IS3 family transposase -
  MOW07_RS06530 (MOW07_06535) - 1373588..1374181 (-) 594 WP_002328085.1 ParB/RepB/Spo0J family partition protein -
  MOW07_RS06535 (MOW07_06540) - 1374591..1376027 (+) 1437 WP_002328084.1 hypothetical protein -
  MOW07_RS06540 (MOW07_06545) - 1376192..1377592 (-) 1401 WP_002287852.1 glutamate decarboxylase -
  MOW07_RS06545 (MOW07_06550) gadC 1377605..1379116 (-) 1512 WP_002287851.1 glutamate:gamma-aminobutyrate antiporter -
  MOW07_RS06550 (MOW07_06555) - 1379573..1380099 (+) 527 Protein_1295 transposase -
  MOW07_RS06555 (MOW07_06560) - 1380254..1380829 (+) 576 WP_002328082.1 thymidine kinase -
  MOW07_RS06560 (MOW07_06565) - 1380943..1382388 (+) 1446 WP_229204866.1 IS1182 family transposase -
  MOW07_RS06565 (MOW07_06570) - 1382441..1382881 (+) 441 WP_002328080.1 helix-turn-helix transcriptional regulator -
  MOW07_RS06570 (MOW07_06575) - 1382923..1384049 (+) 1127 WP_126305265.1 IS3 family transposase -
  MOW07_RS06575 (MOW07_06580) - 1384151..1384903 (+) 753 WP_249456173.1 threonine/serine exporter family protein -
  MOW07_RS06580 (MOW07_06585) - 1384919..1385410 (+) 492 WP_002328076.1 threonine/serine exporter family protein -
  MOW07_RS06585 (MOW07_06590) - 1385552..1386415 (-) 864 WP_235692261.1 TIGR03943 family protein -
  MOW07_RS06590 (MOW07_06595) - 1386426..1387358 (-) 933 WP_231450508.1 permease -
  MOW07_RS06595 (MOW07_06600) - 1387573..1387920 (+) 348 WP_160232001.1 thioredoxin family protein -
  MOW07_RS06600 (MOW07_06605) - 1388213..1388473 (-) 261 WP_002328071.1 hypothetical protein -
  MOW07_RS06605 (MOW07_06610) - 1388628..1389774 (+) 1147 Protein_1306 IS3 family transposase -
  MOW07_RS06610 (MOW07_06615) - 1389968..1390732 (-) 765 WP_126305262.1 hypothetical protein -
  MOW07_RS06615 (MOW07_06620) - 1390909..1392201 (-) 1293 WP_002346666.1 hypothetical protein -
  MOW07_RS06620 (MOW07_06625) - 1392176..1393948 (-) 1773 WP_249456175.1 AAA family ATPase -
  MOW07_RS06625 (MOW07_06630) - 1394063..1397212 (-) 3150 WP_249456177.1 HsdR family type I site-specific deoxyribonuclease -
  MOW07_RS06630 (MOW07_06635) - 1397225..1398331 (-) 1107 WP_249456179.1 restriction endonuclease subunit S -
  MOW07_RS06635 (MOW07_06640) - 1398321..1399916 (-) 1596 WP_249456181.1 type I restriction-modification system subunit M -
  MOW07_RS13830 - 1400098..1400322 (-) 225 Protein_1313 hypothetical protein -
  MOW07_RS06640 (MOW07_06645) - 1400376..1401056 (-) 681 WP_231414838.1 IS6-like element IS1216 family transposase -
  MOW07_RS06645 (MOW07_06650) - 1401330..1402067 (-) 738 WP_152133491.1 SIS domain-containing protein -
  MOW07_RS06650 (MOW07_06655) - 1402069..1403319 (-) 1251 WP_003125789.1 PTS ascorbate transporter subunit IIC -
  MOW07_RS06655 (MOW07_06660) - 1403322..1403603 (-) 282 WP_002301437.1 PTS sugar transporter subunit IIB -
  MOW07_RS06660 (MOW07_06665) - 1403616..1404047 (-) 432 WP_249456183.1 PTS sugar transporter subunit IIA -
  MOW07_RS06665 (MOW07_06670) - 1404044..1405681 (-) 1638 WP_005470693.1 PRD domain-containing protein -
  MOW07_RS06670 (MOW07_06675) - 1405895..1406788 (+) 894 WP_152133489.1 neutral zinc metallopeptidase -
  MOW07_RS06680 (MOW07_06685) - 1407367..1407807 (+) 441 WP_249456185.1 helix-turn-helix domain-containing protein -
  MOW07_RS06685 (MOW07_06690) - 1407840..1409477 (-) 1638 WP_104762051.1 recombinase family protein -
  MOW07_RS06690 (MOW07_06695) - 1409481..1410854 (-) 1374 WP_104762052.1 recombinase family protein -
  MOW07_RS06695 (MOW07_06700) - 1411120..1411386 (-) 267 WP_249456187.1 hypothetical protein -
  MOW07_RS06700 (MOW07_06705) - 1411361..1411525 (-) 165 WP_002340116.1 hypothetical protein -
  MOW07_RS06705 (MOW07_06710) - 1411569..1412402 (-) 834 WP_249456189.1 replication initiation factor domain-containing protein -
  MOW07_RS06710 (MOW07_06715) - 1412573..1413739 (+) 1167 WP_249456192.1 hypothetical protein -
  MOW07_RS06715 (MOW07_06720) - 1414253..1414615 (-) 363 WP_194178083.1 DUF4180 domain-containing protein -
  MOW07_RS06720 (MOW07_06725) - 1414626..1415396 (-) 771 WP_096709896.1 alpha/beta hydrolase -
  MOW07_RS06725 (MOW07_06730) - 1415706..1416868 (-) 1163 Protein_1330 IS3 family transposase -
  MOW07_RS06730 (MOW07_06735) - 1416942..1417223 (-) 282 Protein_1331 hypothetical protein -
  MOW07_RS06735 (MOW07_06740) - 1417298..1417594 (-) 297 WP_029485635.1 hypothetical protein -
  MOW07_RS06740 (MOW07_06745) - 1417587..1417879 (-) 293 Protein_1333 Mor transcription activator family protein -
  MOW07_RS06745 (MOW07_06750) - 1418025..1418576 (-) 552 WP_002312616.1 DUF1643 domain-containing protein -
  MOW07_RS06750 (MOW07_06755) - 1418750..1419049 (-) 300 WP_002312614.1 hypothetical protein -
  MOW07_RS06755 (MOW07_06760) - 1419076..1419384 (-) 309 WP_002317115.1 DUF960 domain-containing protein -
  MOW07_RS06760 (MOW07_06765) - 1419538..1420386 (-) 849 WP_002331982.1 hypothetical protein -
  MOW07_RS06765 (MOW07_06770) rlmH 1420436..1420915 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  MOW07_RS06770 (MOW07_06775) htrA 1421368..1422654 (+) 1287 WP_088774953.1 trypsin-like peptidase domain-containing protein Regulator

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44609.73 Da        Isoelectric Point: 4.7976

>NTDB_id=665536 MOW07_RS06770 WP_088774953.1 1421368..1422654(+) (htrA) [Enterococcus hirae strain GDIAS-5]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAVSNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=665536 MOW07_RS06770 WP_088774953.1 1421368..1422654(+) (htrA) [Enterococcus hirae strain GDIAS-5]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGTGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTCGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTAGAAGGGCAACAAGGATTAGAAGTTTTATTAAAAGATGGTACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTAAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)

Trypsin-like peptidase domain (Trypsin_2)

(124-269)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453