Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SRT_RS04665 Genome accession   NZ_AP014612
Coordinates   916322..916996 (+) Length   224 a.a.
NCBI ID   WP_128833223.1    Uniprot ID   A0A1L7LIZ7
Organism   Streptococcus troglodytae strain TKU 31     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 911322..921996
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SRT_RS04645 (SRT_09060) pstB 911570..912328 (+) 759 WP_128833219.1 phosphate ABC transporter ATP-binding protein PstB -
  SRT_RS04650 (SRT_09070) phoU 912360..913013 (+) 654 WP_128833220.1 phosphate signaling complex protein PhoU -
  SRT_RS04655 (SRT_09080) - 913055..915604 (+) 2550 WP_128833221.1 M1 family metallopeptidase -
  SRT_RS04660 (SRT_09090) - 916005..916271 (+) 267 WP_128833222.1 hypothetical protein -
  SRT_RS04665 (SRT_09100) ciaR 916322..916996 (+) 675 WP_128833223.1 three-component system response regulator CiaR Regulator
  SRT_RS04670 (SRT_09110) ciaH 916986..918292 (+) 1307 Protein_870 three-component system sensor histidine kinase CiaH -
  SRT_RS04675 (SRT_09120) rpsT 918379..918614 (-) 236 Protein_871 30S ribosomal protein S20 -
  SRT_RS04680 (SRT_09130) coaA 918686..919606 (-) 921 WP_128833224.1 type I pantothenate kinase -
  SRT_RS04685 (SRT_09140) - 919702..920298 (+) 597 WP_128833225.1 class I SAM-dependent methyltransferase -
  SRT_RS04690 (SRT_09150) - 920404..921680 (+) 1277 Protein_874 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25493.26 Da        Isoelectric Point: 4.3425

>NTDB_id=66175 SRT_RS04665 WP_128833223.1 916322..916996(+) (ciaR) [Streptococcus troglodytae strain TKU 31]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVEMLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=66175 SRT_RS04665 WP_128833223.1 916322..916996(+) (ciaR) [Streptococcus troglodytae strain TKU 31]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGCGGCGTTTATGATTTAATCCTATTAGACTTGATGC
TTCCTGAAAAAAATGGTTTTCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACAACGCCTGTTTTGATTATGACAGCT
AAAGAAGGTTTGGATGACAAAGGGCATGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTCTATCTTGAAGA
ATTAAAAATGCGTATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTCAACGAAAATAATCTGACTTACGGTGAATTAACCG
TTGATACAGCAACTAATACAACAATGGTAAACGGAAAAGAAGTTGAGATGCTCGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTGCAAAATCAAAACGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATCAGAAAAAAATTAAAAGACACCACATTTGGAAAAAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L7LIZ7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

99.554

100

0.996
  ciaR Streptococcus pneumoniae Rx1

87.946

100

0.879
  ciaR Streptococcus pneumoniae D39

87.946

100

0.879
  ciaR Streptococcus pneumoniae R6

87.946

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366

Multiple sequence alignment