Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   SRT_RS00275 Genome accession   NZ_AP014612
Coordinates   39078..40001 (+) Length   307 a.a.
NCBI ID   WP_128832649.1    Uniprot ID   A0A1L7LGP4
Organism   Streptococcus troglodytae strain TKU 31     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 35582..51430 39078..40001 within 0


Gene organization within MGE regions


Location: 35582..51430
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SRT_RS00260 (SRT_00340) - 36315..37136 (+) 822 WP_128832647.1 ABC transporter ATP-binding protein -
  SRT_RS00265 (SRT_00350) - 37126..37845 (+) 720 WP_128832648.1 hypothetical protein -
  SRT_RS00270 - 37990..38887 (+) 898 Protein_33 helix-turn-helix domain-containing protein -
  SRT_RS00275 (SRT_00380) comA 39078..40001 (+) 924 WP_128832649.1 cysteine peptidase family C39 domain-containing protein Regulator
  SRT_RS11075 - 40078..40323 (+) 246 Protein_35 ABC transporter transmembrane domain-containing protein -
  SRT_RS00285 - 40603..41184 (+) 582 Protein_36 ATP-binding cassette domain-containing protein -
  SRT_RS00290 (SRT_00410) purC 41305..42012 (+) 708 WP_128832650.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SRT_RS00295 (SRT_00430) - 42022..45746 (+) 3725 Protein_38 phosphoribosylformylglycinamidine synthase -
  SRT_RS00300 (SRT_00440) purF 45985..47424 (+) 1440 WP_128832651.1 amidophosphoribosyltransferase -
  SRT_RS10305 (SRT_00450) - 47437..47922 (+) 486 WP_161939999.1 hypothetical protein -
  SRT_RS00310 (SRT_00460) purM 47965..48987 (+) 1023 WP_128832652.1 phosphoribosylformylglycinamidine cyclo-ligase -
  SRT_RS00315 (SRT_00470) purN 48987..49541 (+) 555 WP_128832653.1 phosphoribosylglycinamide formyltransferase -
  SRT_RS00325 (SRT_00480) purH 49880..51430 (+) 1551 WP_128832654.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -

Sequence

Protein


Download         Length: 307 a.a.        Molecular weight: 34523.35 Da        Isoelectric Point: 7.3724

>NTDB_id=66147 SRT_RS00275 WP_128832649.1 39078..40001(+) (comA) [Streptococcus troglodytae strain TKU 31]
MTRYSYISQGDERDCGVAALAMILKHYGSKYSLAYLRELAQTSREGTSALGLIEAAKQLGMKTKAIRADMQLFDEEELVY
PFIVYVVKNESLQHYYTIFGQKNGQLIIGDPDPSRKMVTMKREDFVKEWTAVALFFEPNEDYTVHKEKIPGLLSFVPILF
KKKDLIATIVTLSFVVTIINVAGSYYLQAMLDSLIPRAAYSVLSIISMGLCVAYIGQQILSFFKDYFLSKLSNYLSAEVI
LPYIKHVLSLPMSFFTSRRTGEITSRFGDASTIIDALASTILSLFLDVTIVLTLALALFIQNHQLFG

Nucleotide


Download         Length: 924 bp        

>NTDB_id=66147 SRT_RS00275 WP_128832649.1 39078..40001(+) (comA) [Streptococcus troglodytae strain TKU 31]
TTGACTCGGTATTCTTATATTTCTCAAGGTGATGAGCGTGATTGCGGAGTAGCGGCTTTGGCGATGATCCTGAAGCATTA
TGGGTCAAAGTATAGTTTGGCTTATCTGAGAGAACTGGCACAGACATCTCGTGAAGGGACATCGGCCTTAGGTTTGATTG
AAGCGGCTAAGCAGTTGGGAATGAAGACAAAGGCCATTCGTGCAGATATGCAGTTATTTGATGAAGAGGAGTTGGTCTAT
CCATTTATTGTGTATGTGGTCAAAAATGAGAGTCTGCAGCATTACTATACTATTTTTGGTCAAAAAAATGGGCAGTTGAT
CATTGGAGACCCTGACCCAAGCCGTAAGATGGTTACGATGAAACGTGAAGATTTTGTCAAGGAATGGACAGCTGTTGCTT
TATTCTTTGAGCCTAATGAAGACTACACGGTTCATAAAGAAAAGATACCGGGCTTGCTCTCCTTTGTTCCTATTCTATTT
AAAAAGAAGGATCTGATTGCGACTATTGTAACTCTTAGCTTTGTCGTAACTATCATCAACGTTGCAGGCTCTTACTATTT
GCAGGCTATGCTGGATAGTCTGATTCCACGCGCTGCTTACTCAGTACTTAGCATTATTTCGATGGGGCTGTGTGTTGCTT
ATATTGGACAGCAGATTCTCTCCTTTTTTAAAGACTATTTCTTAAGCAAACTGAGTAATTATTTATCGGCTGAGGTGATT
TTGCCCTATATTAAGCATGTTCTGTCTTTGCCAATGAGTTTTTTCACTTCACGGCGGACAGGAGAAATTACTTCTCGATT
TGGAGATGCCAGTACCATCATTGATGCTCTGGCTTCAACCATACTTTCGCTCTTTTTGGATGTTACCATTGTACTTACTT
TGGCTCTTGCCTTATTTATTCAAAACCATCAACTTTTTGGCTGA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-305)

Peptidase C39 family (Peptidase_C39)

(4-140)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1L7LGP4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis SK321

54.605

99.023

0.541
  comA Streptococcus pneumoniae R6

54.276

99.023

0.537
  comA Streptococcus mitis NCTC 12261

54.276

99.023

0.537
  comA Streptococcus pneumoniae TIGR4

54.276

99.023

0.537
  comA Streptococcus pneumoniae Rx1

54.276

99.023

0.537
  comA Streptococcus pneumoniae D39

54.276

99.023

0.537
  comA/nlmT Streptococcus mutans UA159

53.947

99.023

0.534
  comA Streptococcus gordonii str. Challis substr. CH1

52.961

99.023

0.524

Multiple sequence alignment