Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   MK801_RS00715 Genome accession   NZ_CP092748
Coordinates   146047..147273 (-) Length   408 a.a.
NCBI ID   WP_012898631.1    Uniprot ID   Q66RU3
Organism   Lactococcus lactis strain 17M1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 141047..152273
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MK801_RS00690 (MK801_00690) - 141186..141938 (+) 753 WP_057720559.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  MK801_RS00695 (MK801_00695) - 141979..142983 (-) 1005 WP_254255599.1 hypothetical protein -
  MK801_RS00700 (MK801_00700) - 143125..143349 (-) 225 WP_003130579.1 YkuJ family protein -
  MK801_RS00705 (MK801_00705) - 143457..144797 (-) 1341 WP_012898632.1 glycosyltransferase family 4 protein -
  MK801_RS00710 (MK801_00710) - 144923..145921 (-) 999 WP_015427177.1 glycosyltransferase family 4 protein -
  MK801_RS00715 (MK801_00715) htrA 146047..147273 (-) 1227 WP_012898631.1 S1C family serine protease Regulator
  MK801_RS00720 (MK801_00720) rlmH 147649..148128 (+) 480 WP_003130585.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  MK801_RS00725 (MK801_00725) - 148147..148845 (+) 699 WP_057720558.1 DNA alkylation repair protein -
  MK801_RS00730 (MK801_00730) yajC 148940..149272 (+) 333 WP_003130588.1 preprotein translocase subunit YajC -
  MK801_RS00735 (MK801_00735) - 149646..150380 (+) 735 WP_003130589.1 isoprenyl transferase -
  MK801_RS00740 (MK801_00740) - 150380..151183 (+) 804 WP_003130590.1 phosphatidate cytidylyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41637.93 Da        Isoelectric Point: 4.9794

>NTDB_id=659946 MK801_RS00715 WP_012898631.1 146047..147273(-) (htrA) [Lactococcus lactis strain 17M1]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=659946 MK801_RS00715 WP_012898631.1 146047..147273(-) (htrA) [Lactococcus lactis strain 17M1]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGCTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGAGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACGGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCTAACACTGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGACGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCGGATGGTAAAATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCACAATTGAAATTACCAAGT
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(250-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RU3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

52.989

90.196

0.478