Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   SMUNUM_RS02400 Genome accession   NZ_AP014571
Coordinates   462708..464558 (+) Length   616 a.a.
NCBI ID   WP_002296942.1    Uniprot ID   -
Organism   Streptococcus mutans LP13     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 457708..469558
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNUM_RS02385 (SMNUM_0425) fmt 459691..460626 (+) 936 WP_002263042.1 methionyl-tRNA formyltransferase -
  SMUNUM_RS02390 (SMNUM_0426) rsmB 460607..461929 (+) 1323 WP_002282801.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  SMUNUM_RS02395 (SMNUM_0427) - 461968..462711 (+) 744 WP_002282802.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SMUNUM_RS02400 (SMNUM_0428) pknB 462708..464558 (+) 1851 WP_002296942.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SMUNUM_RS02405 (SMNUM_0429) liaF 464999..465694 (+) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  SMUNUM_RS02410 (SMNUM_0430) - 465691..466695 (+) 1005 WP_002263037.1 sensor histidine kinase -
  SMUNUM_RS02415 (SMNUM_0431) - 466688..467329 (+) 642 WP_002263036.1 response regulator transcription factor -
  SMUNUM_RS02420 (SMNUM_0432) - 467373..468788 (+) 1416 WP_002263035.1 Cof-type HAD-IIB family hydrolase -
  SMUNUM_RS02425 (SMNUM_0433) - 468772..469158 (+) 387 WP_002263034.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66955.74 Da        Isoelectric Point: 9.4520

>NTDB_id=65961 SMUNUM_RS02400 WP_002296942.1 462708..464558(+) (pknB) [Streptococcus mutans LP13]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGTGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNIVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=65961 SMUNUM_RS02400 WP_002296942.1 462708..464558(+) (pknB) [Streptococcus mutans LP13]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGCATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGGATTATGCTTTTTGAAATGCTGACAGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTACTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGACTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTTAGTACTTTAACAGCTATGGGGATTTCTTCAAGTCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATATTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-258)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(438-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

99.675

100

0.997
  stkP/pknB Streptococcus salivarius strain HSISS4

63.087

96.753

0.61
  stkP Streptococcus pneumoniae TIGR4

52.217

98.864

0.516
  stkP Streptococcus pneumoniae D39

52.053

98.864

0.515
  stkP Streptococcus pneumoniae R6

52.053

98.864

0.515
  stkP Streptococcus pneumoniae Rx1

51.888

98.864

0.513

Multiple sequence alignment