Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   L5I22_RS12480 Genome accession   NZ_CP091892
Coordinates   2586337..2587635 (+) Length   432 a.a.
NCBI ID   WP_002368406.1    Uniprot ID   R3K7C6
Organism   Enterococcus faecalis strain 133-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2581337..2592635
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L5I22_RS12475 (L5I22_12475) rlmH 2585457..2585936 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  L5I22_RS12480 (L5I22_12480) htrA 2586337..2587635 (+) 1299 WP_002368406.1 trypsin-like peptidase domain-containing protein Regulator
  L5I22_RS12485 (L5I22_12485) ytpR 2587682..2588302 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  L5I22_RS12490 (L5I22_12490) - 2588406..2589230 (-) 825 WP_002385250.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  L5I22_RS12495 (L5I22_12495) - 2589214..2589984 (-) 771 WP_002365320.1 PTS sugar transporter subunit IIC -
  L5I22_RS12500 (L5I22_12500) - 2590006..2590479 (-) 474 WP_002359087.1 PTS sugar transporter subunit IIB -
  L5I22_RS12505 (L5I22_12505) - 2590482..2591225 (-) 744 WP_010710898.1 BtpA/SgcQ family protein -
  L5I22_RS12510 (L5I22_12510) - 2591237..2591647 (-) 411 WP_002359084.1 PTS sugar transporter subunit IIA -
  L5I22_RS12515 (L5I22_12515) - 2591662..2592393 (-) 732 WP_002365323.1 GntR family transcriptional regulator -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44831.95 Da        Isoelectric Point: 4.9968

>NTDB_id=654406 L5I22_RS12480 WP_002368406.1 2586337..2587635(+) (htrA) [Enterococcus faecalis strain 133-1]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=654406 L5I22_RS12480 WP_002368406.1 2586337..2587635(+) (htrA) [Enterococcus faecalis strain 133-1]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCAGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGCG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTGTCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAATTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCGATTG
GTTCCCCGCTAGGCTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCCATTAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACACGACCAGCT
CTTGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R3K7C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456