Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   L3474_RS06425 Genome accession   NZ_CP091450
Coordinates   1292156..1292830 (-) Length   224 a.a.
NCBI ID   WP_000590640.1    Uniprot ID   D4I4V1
Organism   Streptococcus pneumoniae strain 3641/15     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1287156..1297830
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L3474_RS06410 (L3474_06360) - 1289442..1290371 (-) 930 WP_000411851.1 peptidase U32 family protein -
  L3474_RS06415 (L3474_06365) - 1290511..1290798 (+) 288 WP_001145226.1 DUF3270 domain-containing protein -
  L3474_RS06420 (L3474_06370) ciaH 1290832..1292166 (-) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  L3474_RS06425 (L3474_06375) ciaR 1292156..1292830 (-) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  L3474_RS06430 (L3474_06380) - 1292939..1295485 (-) 2547 WP_001149107.1 M1 family metallopeptidase -
  L3474_RS06435 (L3474_06385) - 1295608..1296048 (-) 441 WP_000188827.1 ASCH domain-containing protein -
  L3474_RS06440 (L3474_06390) - 1296023..1296892 (-) 870 WP_001245817.1 putative PEP-binding protein -
  L3474_RS06445 (L3474_06395) - 1296870..1297370 (-) 501 WP_000403351.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=651250 L3474_RS06425 WP_000590640.1 1292156..1292830(-) (ciaR) [Streptococcus pneumoniae strain 3641/15]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=651250 L3474_RS06425 WP_000590640.1 1292156..1292830(-) (ciaR) [Streptococcus pneumoniae strain 3641/15]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D4I4V1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

100

100

1
  ciaR Streptococcus pneumoniae D39

100

100

1
  ciaR Streptococcus pneumoniae R6

100

100

1
  ciaR Streptococcus pneumoniae TIGR4

100

100

1
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371