Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   L3474_RS04135 Genome accession   NZ_CP091450
Coordinates   820832..821569 (+) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae strain 3641/15     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 815832..826569
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L3474_RS04115 (L3474_04085) - 816029..817132 (+) 1104 WP_000225901.1 glycosyltransferase -
  L3474_RS04120 (L3474_04090) - 817134..818120 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  L3474_RS04125 (L3474_04095) - 818136..819569 (+) 1434 WP_000565084.1 O-antigen polysaccharide polymerase Wzy family protein -
  L3474_RS04130 (L3474_04100) - 819598..820632 (+) 1035 WP_000461498.1 hypothetical protein -
  L3474_RS04135 (L3474_04105) mecA 820832..821569 (+) 738 WP_000782676.1 adaptor protein MecA Regulator
  L3474_RS04140 (L3474_04110) - 821720..823006 (+) 1287 WP_000216372.1 homoserine dehydrogenase -
  L3474_RS04145 (L3474_04115) thrB 823008..823877 (+) 870 WP_000692436.1 homoserine kinase -
  L3474_RS04150 (L3474_04120) - 823953..824189 (+) 237 WP_000693047.1 hypothetical protein -
  L3474_RS04155 (L3474_04125) msrB 824218..825156 (+) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=651239 L3474_RS04135 WP_000782676.1 820832..821569(+) (mecA) [Streptococcus pneumoniae strain 3641/15]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=651239 L3474_RS04135 WP_000782676.1 820832..821569(+) (mecA) [Streptococcus pneumoniae strain 3641/15]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482