Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   L1O50_RS01285 Genome accession   NZ_CP090955
Coordinates   314539..315801 (+) Length   420 a.a.
NCBI ID   WP_029237456.1    Uniprot ID   A0A1X4JLK3
Organism   Weissella cibaria strain CXO-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 309539..320801
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1O50_RS01270 (L1O50_01270) yycH 311385..312710 (+) 1326 WP_010372070.1 two-component system activity regulator YycH -
  L1O50_RS01275 (L1O50_01275) - 312710..313522 (+) 813 WP_010372067.1 two-component system regulatory protein YycI -
  L1O50_RS01280 (L1O50_01280) - 313615..314424 (+) 810 WP_038228981.1 MBL fold metallo-hydrolase -
  L1O50_RS01285 (L1O50_01285) htrA 314539..315801 (+) 1263 WP_029237456.1 S1C family serine protease Regulator
  L1O50_RS01290 (L1O50_01290) - 316140..316577 (-) 438 WP_010372059.1 DUF1934 domain-containing protein -
  L1O50_RS01295 (L1O50_01295) - 316683..318041 (+) 1359 WP_010372056.1 HD domain-containing protein -
  L1O50_RS01300 (L1O50_01300) yidA 318087..318923 (+) 837 WP_010372054.1 sugar-phosphatase -
  L1O50_RS01305 (L1O50_01305) rpoE 319004..319597 (+) 594 WP_010372050.1 DNA-directed RNA polymerase subunit delta -
  L1O50_RS01310 (L1O50_01310) pnuC 319803..320600 (+) 798 WP_010372047.1 nicotinamide riboside transporter PnuC -

Sequence

Protein


Download         Length: 420 a.a.        Molecular weight: 42751.56 Da        Isoelectric Point: 4.9746

>NTDB_id=646639 L1O50_RS01285 WP_029237456.1 314539..315801(+) (htrA) [Weissella cibaria strain CXO-1]
MKKTSTTKIAIIGIVAGLVGGGAAAGGVTYLNNAGTFSTVTTGKTTPVKVSNSNVKGESDATKAFNKVSGAVVSVINLQK
QQSLSDSGSLFGGLFGGDESSSSDSKSTDSSDLQTASEGSGVVYKKDGNTAYIVTNNHVVSGSNALQVLLSDGTKLTATL
VGTDEQTDLAVLKINASKVSEVADFANSSKIEPGQSVLAIGSPLGSEYATSVTEGIISATKREVDATNENGDSLGKATVI
QTDAAINPGNSGGPLVNLAGQVVGINSMKLASSTDGTSVEGMGFAIPANTVVNIINELEKNGKVERPALGVSMVDLSNVS
TTDQSTILKLPTSVSGGVVVISTEDGSAAATAGLKKYDVITKIDDTEVTGSGDLRDALYKHKVGDTIKVTYYRDGKQKTT
DVKLTKTTSSLSTKSEANQN

Nucleotide


Download         Length: 1263 bp        

>NTDB_id=646639 L1O50_RS01285 WP_029237456.1 314539..315801(+) (htrA) [Weissella cibaria strain CXO-1]
ATGAAAAAGACATCAACCACAAAAATAGCAATTATCGGGATTGTTGCCGGGCTAGTCGGCGGTGGTGCCGCTGCTGGTGG
CGTAACTTACCTGAATAATGCCGGCACTTTTTCAACAGTTACGACTGGTAAGACGACACCGGTGAAGGTAAGTAACTCGA
ACGTGAAGGGCGAATCTGATGCAACGAAGGCCTTTAACAAGGTGTCGGGCGCAGTTGTGTCAGTGATTAACTTGCAAAAG
CAACAATCACTTTCAGACAGCGGCTCATTATTTGGTGGGTTGTTTGGTGGTGATGAGTCATCGTCAAGTGATAGCAAGTC
AACAGATTCATCAGACCTTCAAACGGCTTCTGAGGGATCAGGAGTGGTTTACAAGAAGGATGGTAACACGGCTTATATCG
TCACGAACAACCACGTGGTTTCAGGGTCAAACGCGTTGCAAGTCTTGTTGAGCGATGGGACTAAGCTGACGGCGACGTTG
GTTGGTACTGATGAGCAAACTGATTTGGCTGTGTTGAAGATTAATGCAAGCAAGGTATCAGAGGTAGCTGACTTTGCTAA
CTCAAGTAAGATTGAGCCGGGACAATCAGTTTTGGCCATCGGGTCACCATTGGGATCAGAGTATGCGACGTCAGTGACAG
AAGGAATCATTTCAGCAACGAAGCGTGAAGTCGATGCCACAAATGAGAATGGTGATTCACTCGGTAAGGCCACGGTTATC
CAAACGGACGCGGCAATTAATCCCGGAAATTCAGGTGGCCCATTGGTAAACTTGGCCGGTCAAGTCGTTGGTATCAACTC
AATGAAGTTGGCATCGTCAACTGACGGTACGTCGGTTGAAGGAATGGGATTTGCGATTCCGGCTAATACGGTAGTCAACA
TCATTAACGAGTTGGAGAAGAATGGAAAGGTTGAACGACCAGCTTTGGGCGTTTCAATGGTTGATTTGAGTAACGTCTCA
ACGACGGATCAATCAACAATCTTGAAGTTGCCAACCAGCGTTTCAGGTGGTGTCGTGGTCATCAGTACTGAAGATGGTTC
AGCAGCAGCGACTGCGGGCTTGAAGAAGTACGATGTGATTACCAAGATTGACGATACTGAGGTTACTGGTTCTGGTGACT
TGCGAGATGCTTTGTATAAGCACAAGGTTGGTGACACGATTAAGGTAACTTACTACCGCGATGGTAAGCAAAAGACGACT
GACGTGAAATTGACGAAGACGACGAGCTCATTATCAACGAAGTCAGAAGCAAATCAAAACTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(194-409)

PDZ domain (PDZ_2)

(307-404)

Trypsin-like peptidase domain (Trypsin_2)

(119-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X4JLK3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

49.637

98.333

0.488
  htrA Streptococcus mutans UA159

50.646

92.143

0.467
  htrA Streptococcus mitis NCTC 12261

48.13

95.476

0.46
  htrA Streptococcus pneumoniae TIGR4

51.676

85.238

0.44
  htrA Streptococcus pneumoniae D39

51.676

85.238

0.44
  htrA Streptococcus pneumoniae Rx1

51.676

85.238

0.44
  htrA Streptococcus pneumoniae R6

51.676

85.238

0.44