Detailed information NTG0064652

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SPYOHK_RS08925
• Genome accession: NZ_AFRY01000001
• Coordinates: 53047..53958 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes HKU QMH11M0907901
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48047..58958

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYOHK_RS08945 (SPYOHK_00145)	purE	48340..48831 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SPYOHK_RS08940 (SPYOHK_00150)	purK	48818..49891 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SPYOHK_RS08935 (SPYOHK_00155)	-	49912..51252 (+)	1341	WP_002987721.1	hypothetical protein	-
SPYOHK_RS08930 (SPYOHK_00160)	purB	51621..52913 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
SPYOHK_RS08925 (SPYOHK_00165)	comR	53047..53958 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
SPYOHK_RS10300	comS	54042..54137 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
SPYOHK_RS08920 (SPYOHK_00170)	ruvB	54184..55182 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
SPYOHK_RS08915 (SPYOHK_00175)	-	55320..55757 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
SPYOHK_RS08910 (SPYOHK_00180)	-	55781..56182 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
SPYOHK_RS08905 (SPYOHK_00185)	-	56179..57954 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=64652 SPYOHK_RS08925 WP_002986681.1 53047..53958(+) (comR) [Streptococcus pyogenes HKU QMH11M0907901]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=64652 SPYOHK_RS08925 WP_002986681.1 53047..53958(+) (comR) [Streptococcus pyogenes HKU QMH11M0907901]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462