Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   L1A19_RS10605 Genome accession   NZ_CP090888
Coordinates   468387..468974 (-) Length   195 a.a.
NCBI ID   WP_000205166.1    Uniprot ID   Q9ETN5
Organism   Streptococcus pneumoniae strain PT8465     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 446827..468974 468387..468974 within 0


Gene organization within MGE regions


Location: 446827..468974
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1A19_RS02265 (L1A19_02265) - 446827..448290 (-) 1464 WP_000029054.1 class I SAM-dependent DNA methyltransferase -
  L1A19_RS02270 (L1A19_02270) - 448303..449481 (-) 1179 Protein_450 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
  L1A19_RS02275 (L1A19_02275) - 449744..450697 (+) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  L1A19_RS02280 (L1A19_02280) - 450731..451882 (-) 1152 Protein_452 DEAD/DEAH box helicase family protein -
  L1A19_RS10475 - 452233..452361 (-) 129 WP_001808901.1 hypothetical protein -
  L1A19_RS02285 (L1A19_02285) - 452490..452999 (+) 510 WP_001088689.1 DUF2812 domain-containing protein -
  L1A19_RS02290 (L1A19_02290) hrcA 453163..454197 (+) 1035 WP_000255781.1 heat-inducible transcriptional repressor HrcA -
  L1A19_RS02295 (L1A19_02295) grpE 454224..454748 (+) 525 WP_000046035.1 nucleotide exchange factor GrpE -
  L1A19_RS02300 (L1A19_02300) dnaK 455178..457001 (+) 1824 WP_000034662.1 molecular chaperone DnaK -
  L1A19_RS02305 (L1A19_02305) - 457092..457367 (+) 276 WP_000386177.1 hypothetical protein -
  L1A19_RS02310 (L1A19_02310) dnaJ 457572..458708 (+) 1137 WP_001841444.1 molecular chaperone DnaJ -
  L1A19_RS02315 (L1A19_02315) - 459030..459269 (-) 240 WP_001813906.1 hypothetical protein -
  L1A19_RS02320 (L1A19_02320) - 459431..459718 (-) 288 WP_000777760.1 hypothetical protein -
  L1A19_RS02325 (L1A19_02325) - 459728..460138 (-) 411 WP_001278301.1 HIT family protein -
  L1A19_RS02330 (L1A19_02330) pptA 460206..460937 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  L1A19_RS02335 (L1A19_02335) - 460934..461983 (+) 1050 WP_000653771.1 ABC transporter permease -
  L1A19_RS02340 (L1A19_02340) - 462151..462480 (-) 330 WP_000132572.1 hypothetical protein -
  L1A19_RS02345 (L1A19_02345) - 462755..463093 (+) 339 WP_000682122.1 LytTR family DNA-binding domain-containing protein -
  L1A19_RS02350 (L1A19_02350) comE/blpR 463098..463835 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  L1A19_RS02355 (L1A19_02355) - 463848..465188 (+) 1341 WP_000275284.1 sensor histidine kinase -
  L1A19_RS02360 (L1A19_02360) blpC 465233..465388 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  L1A19_RS02365 (L1A19_02365) - 465445..466806 (-) 1362 WP_001069095.1 bacteriocin secretion accessory protein -
  L1A19_RS02370 (L1A19_02370) - 466817..468493 (-) 1677 Protein_471 peptide cleavage/export ABC transporter -
  L1A19_RS10605 comA/nlmT 468387..468974 (-) 588 WP_000205166.1 cysteine peptidase family C39 domain-containing protein Regulator

Sequence

Protein


Download         Length: 195 a.a.        Molecular weight: 22270.71 Da        Isoelectric Point: 9.6188

>NTDB_id=646098 L1A19_RS10605 WP_000205166.1 468387..468974(-) (comA/nlmT) [Streptococcus pneumoniae strain PT8465]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide


Download         Length: 588 bp        

>NTDB_id=646098 L1A19_RS10605 WP_000205166.1 468387..468974(-) (comA/nlmT) [Streptococcus pneumoniae strain PT8465]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9ETN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

59.89

93.333

0.559
  comA Streptococcus mitis NCTC 12261

54.891

94.359

0.518
  comA Streptococcus mitis SK321

54.348

94.359

0.513
  comA Streptococcus pneumoniae TIGR4

53.804

94.359

0.508
  comA Streptococcus pneumoniae Rx1

53.804

94.359

0.508
  comA Streptococcus pneumoniae D39

53.804

94.359

0.508
  comA Streptococcus pneumoniae R6

53.804

94.359

0.508
  comA Streptococcus gordonii str. Challis substr. CH1

52.717

94.359

0.497