NTDB

Overview

Name	comA/nlmT	Type	Regulator
Locus tag	L1A18_RS10720	Genome accession	NZ_CP090887
Coordinates	460845..461432 (-)	Length	195 a.a.
NCBI ID	WP_000205166.1	Uniprot ID	Q9ETN5
Organism	Streptococcus pneumoniae strain NP7536
Function	transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 455845..466432

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A18_RS02305 (L1A18_02305)	-	456306..457646 (+)	1341	WP_000275284.1	sensor histidine kinase	-
L1A18_RS02310 (L1A18_02310)	blpC	457691..457846 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
L1A18_RS02315 (L1A18_02315)	-	457903..459264 (-)	1362	WP_001069095.1	bacteriocin secretion accessory protein	-
L1A18_RS02320 (L1A18_02320)	-	459275..460951 (-)	1677	Protein_457	peptide cleavage/export ABC transporter	-
L1A18_RS10720	comA/nlmT	460845..461432 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
L1A18_RS02325 (L1A18_02325)	-	461722..461952 (+)	231	WP_001093270.1	hypothetical protein	-
L1A18_RS02330 (L1A18_02330)	blpN	461968..462171 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
L1A18_RS02335 (L1A18_02335)	-	462415..462648 (+)	234	WP_000379963.1	hypothetical protein	-
L1A18_RS02340 (L1A18_02340)	-	462680..463369 (+)	690	WP_000760515.1	CPBP family intramembrane glutamic endopeptidase	-
L1A18_RS02345 (L1A18_02345)	blpZ	463411..463644 (+)	234	WP_000276498.1	immunity protein BlpZ	-
L1A18_RS02350 (L1A18_02350)	-	463795..464406 (+)	612	WP_000394028.1	type II CAAX endopeptidase family protein	-
L1A18_RS02355 (L1A18_02355)	-	464568..465362 (+)	795	WP_000363002.1	phosphotransferase family protein	-
L1A18_RS02360 (L1A18_02360)	trmB	465359..465994 (+)	636	WP_001266078.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-

Sequence

Protein

Download Length: 195 a.a. Molecular weight: 22270.71 Da Isoelectric Point: 9.6188

                                >NTDB_id=646025 L1A18_RS10720 WP_000205166.1 460845..461432(-) (comA/nlmT) [Streptococcus pneumoniae strain NP7536]

MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV

PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS

SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

Download Length: 588 bp

                                >NTDB_id=646025 L1A18_RS10720 WP_000205166.1 460845..461432(-) (comA/nlmT) [Streptococcus pneumoniae strain NP7536]

ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA

ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA

TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC

CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA

TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG

TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC

TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT

CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q9ETN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497

Detailed information NTG0646025