Detailed information NTG0064513

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SMSK321_RS08640
• Genome accession: NZ_AEDT01000026
• Coordinates: 57217..57954 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219153.1
• Uniprot ID: -
• Organism: Streptococcus mitis SK321
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 52217..62954

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMSK321_RS08610 (SMSK321_1147)	dnaJ	52562..53698 (+)	1137	WP_001066321.1	molecular chaperone DnaJ	-
SMSK321_RS08615 (SMSK321_1148)	-	53977..54264 (-)	288	WP_000777748.1	hypothetical protein	-
SMSK321_RS08620 (SMSK321_1149)	-	54274..54684 (-)	411	WP_001278320.1	HIT family protein	-
SMSK321_RS08625 (SMSK321_1150)	pptA	54752..55483 (+)	732	WP_000889953.1	ABC transporter ATP-binding protein	Regulator
SMSK321_RS08630 (SMSK321_1151)	pptB	55480..56529 (+)	1050	WP_000653758.1	ABC transporter permease	Regulator
SMSK321_RS08635 (SMSK321_1152)	-	56592..56921 (-)	330	WP_000132580.1	hypothetical protein	-
SMSK321_RS08640 (SMSK321_1153)	comE/blpR	57217..57954 (+)	738	WP_001219153.1	response regulator transcription factor	Regulator
SMSK321_RS08645 (SMSK321_1154)	-	57968..59317 (+)	1350	WP_001017630.1	sensor histidine kinase	-
SMSK321_RS11840	-	59386..59742 (+)	357	WP_080550772.1	hypothetical protein	-
SMSK321_RS0102520	-	60032..60151 (+)	120	WP_000346299.1	PncF family bacteriocin immunity protein	-
SMSK321_RS08650 (SMSK321_1156)	-	60603..61007 (+)	405	WP_000846947.1	hypothetical protein	-
SMSK321_RS08655 (SMSK321_1157)	blpZ	61066..61314 (+)	249	WP_000278084.1	immunity protein BlpZ	-
SMSK321_RS08660 (SMSK321_1158)	-	61345..61956 (+)	612	WP_000974181.1	CPBP family intramembrane glutamic endopeptidase	-
SMSK321_RS08665 (SMSK321_1160)	ccrZ	62117..62911 (+)	795	WP_000363005.1	cell cycle regulator CcrZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28842.00 Da
• Isoelectric Point: 6.3073

>NTDB_id=64513 SMSK321_RS08640 WP_001219153.1 57217..57954(+) (comE/blpR) [Streptococcus mitis SK321]
MRIFVLEDDFSQQTRIETTIEKLMKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLFFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=64513 SMSK321_RS08640 WP_001219153.1 57217..57954(+) (comE/blpR) [Streptococcus mitis SK321]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAGCAGACTAGGATTGAAACGACGATTGAGAAACTCATGAAAGAACA
TCATATCACTCCCAGTTCTTTTGAAGTCTTTGGTAAGCCAGATCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCGCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCTCTCATCGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTCTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGTTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAC
CTTGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGATAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGTCATCGCTCTTTTCTCATTAATCCTGCCAATGTGGTTCGTTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGGGGAAGCTGTATGATAGCGCGTTATAAGGTCAGAGAAGTGTCTGAGGCT
ATCAATAATTTGCATTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363