Detailed information NTG0639463

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: LXA49_RS11070
• Genome accession: NZ_CP089949
• Coordinates: 2149734..2150915 (+)
• Length: 393 a.a.
• NCBI ID: WP_252948152.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SN75752
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2144734..2155915

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LXA49_RS11030 (LXA49_11015)	-	2145785..2146327 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
LXA49_RS11045 (LXA49_11030)	comE	2146570..2147322 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
LXA49_RS11050 (LXA49_11035)	comD/comD1	2147319..2148644 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
LXA49_RS11055 (LXA49_11040)	comC/comC1	2148665..2148790 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
LXA49_RS11065 (LXA49_11050)	rlmH	2149072..2149551 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LXA49_RS11070 (LXA49_11055)	htrA	2149734..2150915 (+)	1182	WP_252948152.1	S1C family serine protease	Regulator
LXA49_RS11075 (LXA49_11060)	spo0J	2150973..2151731 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41854.72 Da
• Isoelectric Point: 6.8902

>NTDB_id=639463 LXA49_RS11070 WP_252948152.1 2149734..2150915(+) (htrA) [Streptococcus pneumoniae strain SN75752]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKNSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=639463 LXA49_RS11070 WP_252948152.1 2149734..2150915(+) (htrA) [Streptococcus pneumoniae strain SN75752]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAATAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.491	100	0.995
htrA	Streptococcus pneumoniae D39	99.491	100	0.995
htrA	Streptococcus pneumoniae R6	99.491	100	0.995
htrA	Streptococcus pneumoniae TIGR4	99.491	100	0.995
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.822	100	0.55