NTDB

Overview

Name	micA	Type	Regulator
Locus tag	LXA49_RS06020	Genome accession	NZ_CP089949
Coordinates	1196018..1196722 (-)	Length	234 a.a.
NCBI ID	WP_000722076.1	Uniprot ID	Q9S1K0
Organism	Streptococcus pneumoniae strain SN75752
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1191018..1201722

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LXA49_RS05990 (LXA49_05980)	-	1191063..1191806 (-)	744	Protein_1200	ion channel	-
LXA49_RS05995 (LXA49_05985)	-	1191853..1192107 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LXA49_RS06000 (LXA49_05990)	relB	1192109..1192351 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
LXA49_RS06005 (LXA49_05995)	-	1192545..1193801 (+)	1257	WP_000530081.1	ISL3 family transposase	-
LXA49_RS06010 (LXA49_06000)	vicX	1193865..1194674 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
LXA49_RS06015 (LXA49_06005)	micB	1194676..1196025 (-)	1350	WP_000886213.1	cell wall metabolism sensor histidine kinase VicK	Regulator
LXA49_RS06020 (LXA49_06010)	micA	1196018..1196722 (-)	705	WP_000722076.1	response regulator YycF	Regulator
LXA49_RS06025 (LXA49_06015)	mutY	1196778..1197953 (-)	1176	WP_000886152.1	A/G-specific adenine glycosylase	-
LXA49_RS11155	-	1198050..1198175 (+)	126	WP_001818232.1	hypothetical protein	-
LXA49_RS06030 (LXA49_06020)	-	1198281..1199951 (-)	1671	WP_000845285.1	formate--tetrahydrofolate ligase	-
LXA49_RS06035 (LXA49_06025)	coaB	1200181..1200870 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
LXA49_RS06040 (LXA49_06030)	coaC	1200882..1201433 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26815.63 Da Isoelectric Point: 4.7164

                                >NTDB_id=639412 LXA49_RS06020 WP_000722076.1 1196018..1196722(-) (micA) [Streptococcus pneumoniae strain SN75752]

MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA

KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT

HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

Download Length: 705 bp

                                >NTDB_id=639412 LXA49_RS06020 WP_000722076.1 1196018..1196722(-) (micA) [Streptococcus pneumoniae strain SN75752]

ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA

AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA

TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC

AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA

GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC

AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC

CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT

CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC

CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
PDB	1NXS
PDB	2A9O
PDB	2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38

Detailed information NTG0639412