Detailed information NTG0636544

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: LUB18_RS01370
• Genome accession: NZ_CP089319
• Coordinates: 275954..277243 (-)
• Length: 429 a.a.
• NCBI ID: WP_002290101.1
• Uniprot ID: A0A828ZUK2
• Organism: Enterococcus faecium strain NMVRE-001
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	274569..275864	275954..277243	flank	90

Gene organization within MGE regions

Location: 274569..277243

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUB18_RS01365 (LUB18_01365)	-	274569..275864 (+)	1296	WP_002297218.1	ISL3-like element ISEfa11 family transposase	-
LUB18_RS01370 (LUB18_01370)	htrA	275954..277243 (-)	1290	WP_002290101.1	S1C family serine protease	Regulator

Sequence

Protein

• Length: 429 a.a.
• Molecular weight: 44916.93 Da
• Isoelectric Point: 4.5419

>NTDB_id=636544 LUB18_RS01370 WP_002290101.1 275954..277243(-) (htrA) [Enterococcus faecium strain NMVRE-001]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide

• Length: 1290 bp

>NTDB_id=636544 LUB18_RS01370 WP_002290101.1 275954..277243(-) (htrA) [Enterococcus faecium strain NMVRE-001]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (10-417)

• Trypsin-like peptidase domain (Trypsin_2) (127-272)

• PDZ domain (PDZ_2) (317-414)

3D structure

• AlphaFold DB: A0A828ZUK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	54.569	91.841	0.501
htrA	Streptococcus mutans UA159	60.169	82.517	0.496
htrA	Streptococcus mitis NCTC 12261	52.778	92.308	0.487
htrA	Streptococcus pneumoniae TIGR4	59.05	78.555	0.464
htrA	Streptococcus pneumoniae Rx1	59.05	78.555	0.464
htrA	Streptococcus pneumoniae D39	59.05	78.555	0.464
htrA	Streptococcus pneumoniae R6	59.05	78.555	0.464