Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   LQF73_RS10435 Genome accession   NZ_CP088015
Coordinates   2101150..2103312 (-) Length   720 a.a.
NCBI ID   WP_060464273.1    Uniprot ID   -
Organism   Lactobacillus crispatus strain M247     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2101150..2164181 2101150..2103312 within 0


Gene organization within MGE regions


Location: 2101150..2164181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LQF73_RS10435 (LQF73_10375) comA 2101150..2103312 (-) 2163 WP_060464273.1 peptide cleavage/export ABC transporter Regulator
  LQF73_RS10440 (LQF73_10380) - 2103436..2104236 (-) 801 WP_005720993.1 LytTR family DNA-binding domain-containing protein -
  LQF73_RS10445 (LQF73_10385) - 2104229..2105557 (-) 1329 WP_005720992.1 GHKL domain-containing protein -
  LQF73_RS10450 - 2105545..2105676 (-) 132 WP_005720990.1 bacteriocin-like peptide, LSEI_2386 family -
  LQF73_RS10455 (LQF73_10390) - 2105794..2107191 (-) 1398 WP_005720989.1 ATP-binding protein -
  LQF73_RS10460 (LQF73_10395) - 2107506..2109812 (-) 2307 WP_005720988.1 glycoside hydrolase family 31 protein -
  LQF73_RS10465 (LQF73_10400) - 2109959..2111362 (-) 1404 WP_005720987.1 FAD-binding oxidoreductase -
  LQF73_RS10470 (LQF73_10405) - 2111570..2111755 (-) 186 WP_005720986.1 hypothetical protein -
  LQF73_RS10475 (LQF73_10410) - 2111770..2111961 (-) 192 WP_005720985.1 hypothetical protein -
  LQF73_RS10480 (LQF73_10415) - 2112037..2112261 (-) 225 WP_060464272.1 hypothetical protein -
  LQF73_RS10485 (LQF73_10420) - 2112410..2112733 (-) 324 WP_005720983.1 bacteriocin immunity protein -
  LQF73_RS10490 (LQF73_10425) - 2112875..2113624 (-) 750 WP_005721782.1 aspartate/glutamate racemase family protein -
  LQF73_RS10495 (LQF73_10430) - 2113634..2115205 (-) 1572 WP_005720979.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase -
  LQF73_RS10500 (LQF73_10435) - 2115258..2116412 (-) 1155 WP_005723778.1 cell wall metabolism sensor histidine kinase WalK -
  LQF73_RS10505 (LQF73_10440) - 2116414..2117100 (-) 687 WP_005720977.1 response regulator transcription factor -
  LQF73_RS10510 (LQF73_10445) - 2117352..2119205 (-) 1854 WP_050756824.1 ABC transporter ATP-binding protein -
  LQF73_RS10515 (LQF73_10450) - 2119227..2120951 (-) 1725 WP_060464365.1 ABC transporter ATP-binding protein -
  LQF73_RS10520 (LQF73_10455) - 2121185..2122555 (+) 1371 WP_005727311.1 IS4 family transposase -
  LQF73_RS10525 (LQF73_10460) - 2122772..2123557 (-) 786 WP_005720972.1 DUF1129 family protein -
  LQF73_RS10530 (LQF73_10465) ychF 2123566..2124666 (-) 1101 WP_005720971.1 redox-regulated ATPase YchF -
  LQF73_RS10535 (LQF73_10470) - 2124720..2124983 (-) 264 WP_005723772.1 DUF951 domain-containing protein -
  LQF73_RS10540 (LQF73_10475) - 2124976..2125863 (-) 888 WP_005723770.1 ParB/RepB/Spo0J family partition protein -
  LQF73_RS10545 (LQF73_10480) - 2125841..2126620 (-) 780 WP_005721788.1 ParA family protein -
  LQF73_RS10550 (LQF73_10485) noc 2126639..2127475 (-) 837 WP_005723768.1 nucleoid occlusion protein -
  LQF73_RS10555 (LQF73_10490) rsmG 2127493..2128215 (-) 723 WP_005723766.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  LQF73_RS10560 (LQF73_10495) - 2128377..2128913 (+) 537 WP_005723764.1 CvpA family protein -
  LQF73_RS11595 - 2129130..2129192 (+) 63 WP_230454479.1 putative holin-like toxin -
  LQF73_RS10565 (LQF73_10500) - 2129332..2130261 (-) 930 WP_005723762.1 FAD:protein FMN transferase -
  LQF73_RS10570 (LQF73_10505) - 2130264..2131055 (-) 792 WP_005723760.1 tyrosine-protein phosphatase -
  LQF73_RS10575 (LQF73_10510) - 2131147..2131695 (-) 549 WP_005723758.1 NADPH-dependent FMN reductase -
  LQF73_RS10580 (LQF73_10515) - 2131709..2132248 (-) 540 WP_005720958.1 NADPH-dependent FMN reductase -
  LQF73_RS10585 (LQF73_10520) - 2132401..2133024 (-) 624 WP_005720956.1 TetR/AcrR family transcriptional regulator -
  LQF73_RS10590 (LQF73_10525) - 2133152..2133394 (-) 243 WP_005721791.1 hypothetical protein -
  LQF73_RS10595 (LQF73_10530) - 2133563..2134969 (+) 1407 WP_118992208.1 ISLre2-like element ISLcr2 family transposase -
  LQF73_RS10600 (LQF73_10535) - 2135111..2136523 (+) 1413 WP_005721792.1 C69 family dipeptidase -
  LQF73_RS10605 (LQF73_10540) - 2136556..2137230 (-) 675 WP_005721793.1 ABC transporter ATP-binding protein -
  LQF73_RS10610 (LQF73_10545) - 2137232..2138331 (-) 1100 Protein_2049 ABC transporter permease -
  LQF73_RS10615 (LQF73_10550) - 2138334..2138858 (-) 525 WP_005721795.1 TetR/AcrR family transcriptional regulator -
  LQF73_RS10620 (LQF73_10555) - 2138977..2139576 (-) 600 WP_005721796.1 histidine phosphatase family protein -
  LQF73_RS10625 (LQF73_10560) - 2139706..2140461 (+) 756 WP_005721797.1 alpha/beta hydrolase -
  LQF73_RS10630 (LQF73_10565) yaaA 2140458..2141219 (-) 762 WP_005721798.1 peroxide stress protein YaaA -
  LQF73_RS10635 (LQF73_10570) - 2141278..2141922 (+) 645 WP_005721800.1 hypothetical protein -
  LQF73_RS10640 (LQF73_10575) - 2142006..2142803 (-) 798 WP_005720097.1 DUF4931 domain-containing protein -
  LQF73_RS10645 (LQF73_10580) - 2142855..2143889 (-) 1035 WP_005729050.1 IS30 family transposase -
  LQF73_RS10650 (LQF73_10585) - 2144139..2145341 (+) 1203 WP_005720095.1 L,D-transpeptidase family protein -
  LQF73_RS10655 (LQF73_10590) - 2145434..2145625 (+) 192 WP_005720094.1 hypothetical protein -
  LQF73_RS10660 (LQF73_10595) - 2145652..2146407 (-) 756 WP_005720093.1 LiaF domain-containing protein -
  LQF73_RS10665 (LQF73_10600) - 2146407..2146859 (-) 453 WP_005720091.1 LytTR family DNA-binding domain-containing protein -
  LQF73_RS10670 (LQF73_10605) - 2147068..2147526 (-) 459 WP_005720089.1 hypothetical protein -
  LQF73_RS10675 (LQF73_10610) - 2147603..2148775 (-) 1173 WP_118992187.1 IS256 family transposase -
  LQF73_RS10680 (LQF73_10615) - 2149187..2150680 (-) 1494 WP_005720087.1 peptide MFS transporter -
  LQF73_RS10685 (LQF73_10620) - 2150925..2151194 (+) 270 WP_020992915.1 hypothetical protein -
  LQF73_RS10690 (LQF73_10625) - 2151444..2152943 (-) 1500 Protein_2065 IS1182 family transposase -
  LQF73_RS10695 (LQF73_10630) nrdE 2153099..2155267 (-) 2169 WP_005720084.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  LQF73_RS10700 (LQF73_10635) nrdI 2155260..2155685 (-) 426 WP_005720082.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  LQF73_RS10705 (LQF73_10640) nrdF 2155666..2156673 (-) 1008 WP_005726600.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  LQF73_RS10710 (LQF73_10645) - 2157073..2158731 (-) 1659 WP_005720079.1 ATP-binding protein -
  LQF73_RS10715 (LQF73_10650) - 2158731..2159408 (-) 678 WP_225520304.1 response regulator transcription factor -
  LQF73_RS10720 (LQF73_10655) phoU 2159485..2160123 (-) 639 WP_005720076.1 phosphate signaling complex protein PhoU -
  LQF73_RS10725 (LQF73_10660) pstB 2160142..2160900 (-) 759 WP_005720075.1 phosphate ABC transporter ATP-binding protein PstB -
  LQF73_RS10730 (LQF73_10665) pstA 2160900..2161775 (-) 876 WP_005720074.1 phosphate ABC transporter permease PstA -
  LQF73_RS10735 (LQF73_10670) pstC 2161778..2162686 (-) 909 WP_005720073.1 phosphate ABC transporter permease subunit PstC -
  LQF73_RS10740 (LQF73_10675) - 2162706..2163593 (-) 888 WP_123811648.1 phosphate ABC transporter substrate-binding protein -
  LQF73_RS10745 (LQF73_10680) - 2163768..2164181 (-) 414 WP_005720071.1 site-specific integrase -

Sequence

Protein


Download         Length: 720 a.a.        Molecular weight: 81317.69 Da        Isoelectric Point: 8.1038

>NTDB_id=632442 LQF73_RS10435 WP_060464273.1 2101150..2103312(-) (comA) [Lactobacillus crispatus strain M247]
MLLQYKSIYVPQVDESDCGVACLAMILKKYHSRVFLAHLRHSARTNLEGTTALGLVKTAQAFNLKTEAVKADMSLFDPDA
DIQYPFIVHVLKQGELLHYYVVIKATKNYLVIADPDPSVGLTKMSKEKFSQEWTGIALFMVPNDDFEPLKEKKQNLWSLF
PYMFKQKKLVTNIILAALLMTIISICSSYFLQGLIDTYIPSGTYQTLSILAIGLLIAYVFNSIFSYGQNFLLDVLGQRLS
IDLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGIVLAIQNSTLFVITLLSLPIY
AVLILSFSKKFEKMNNDQMESNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTFI
QLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQNRLNEVYMVKSEFQKDAQIRDAK
QLAGEIEYHHVDYHYGYGVDVLKDINLKIEPNDKLAIVGMSGSGKSTMVKLLVDFFSPSKGKLTFNGFNSTKVDKHVLRS
YVNYVPQTPYIFSGTIKENLLLGSRPDITEKDILKACQIAEIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLS
PAKILIFDEATSGLDTITEKKVVDNLMKLKDKTIIFIAHRLAIAQRTNNIVVVDHGQIVEQGSHEKLMQKHGFYYNLVEN

Nucleotide


Download         Length: 2163 bp        

>NTDB_id=632442 LQF73_RS10435 WP_060464273.1 2101150..2103312(-) (comA) [Lactobacillus crispatus strain M247]
ATGTTACTACAGTATAAATCAATTTATGTACCACAAGTAGACGAATCAGATTGTGGAGTTGCATGCTTAGCTATGATTCT
TAAAAAATATCATTCTAGAGTATTTTTAGCCCATTTACGTCATTCAGCCCGCACTAATTTAGAAGGGACTACCGCTCTGG
GCTTAGTTAAAACAGCACAAGCATTTAATCTAAAAACTGAAGCAGTTAAAGCTGACATGTCCTTGTTTGATCCTGATGCA
GACATTCAATATCCTTTCATCGTACACGTCTTAAAGCAAGGCGAATTACTCCACTATTATGTTGTGATTAAGGCAACCAA
AAATTATTTAGTGATTGCTGATCCGGATCCTAGCGTTGGTTTAACGAAAATGTCTAAAGAAAAGTTTTCTCAAGAATGGA
CGGGAATTGCCCTTTTTATGGTCCCAAATGATGATTTTGAGCCACTCAAAGAGAAAAAGCAAAATCTGTGGTCACTATTT
CCATACATGTTCAAACAAAAGAAACTAGTCACTAATATTATTTTGGCTGCTCTTTTGATGACAATCATTAGTATTTGTAG
CTCATACTTCTTGCAAGGCTTAATTGATACTTATATTCCTAGCGGTACATACCAAACTTTGTCGATCCTAGCTATTGGTT
TATTGATAGCATATGTTTTCAACTCTATCTTTTCTTACGGGCAAAATTTTCTATTGGATGTTCTAGGTCAGCGATTAAGT
ATTGATCTTAACTTACAATACATTCGCCATATTTTTGAATTACCAATGGAATTCTTCGTAACTCGTAGAACAGGGGAAAT
TACCTCAAGGTTCTCTGATGCTAGTCGAATTATTGACGCACTCGCCAGTACAGTTATTTCATTATTTCTTGATCTTTCAA
TTGTAATTGTGATGGGAATAGTTTTGGCAATTCAAAATTCCACTCTATTTGTGATTACTCTACTGTCTTTGCCAATTTAT
GCAGTGTTGATTCTTAGCTTTTCTAAGAAATTTGAAAAGATGAATAATGATCAGATGGAGAGTAATGCTGTCTTAAGTTC
TTCAGTAATTGAAGATATTCAAGGAATTGAAACAATCAAAGCTTTAAATAGCGAACAAACACGTTATCGTAAGATTGATA
GTCAATTCGTCGATTACCTCAAGAAATCTTTTCGTTACAGTAAAACTGAATCTTTGCAGTCAGCTTTAAAGACCTTCATT
CAGTTATCTCTCAATGTAATTATCCTCTGGGTAGGGGCTAAGGTTGTAATGAACGGGCAGATGAGCATTGGTCAATTAAT
GACCTTCAACGCATTACTATCGTATTTTGTAGATCCACTTCAGAGCATTATTAATCTTCAACCAACTCTACAATCAGCTA
ATGTAGCACAAAATCGATTGAATGAAGTATACATGGTTAAGAGTGAGTTCCAGAAAGATGCTCAGATTAGGGATGCCAAG
CAATTAGCAGGTGAGATTGAATATCATCATGTTGACTATCATTATGGCTATGGAGTCGATGTATTAAAAGATATTAATTT
AAAAATCGAACCCAATGATAAGTTGGCAATCGTAGGGATGAGTGGCTCAGGTAAGTCTACTATGGTCAAACTTTTAGTTG
ATTTCTTCTCTCCAAGCAAAGGCAAGTTAACTTTTAATGGATTTAATTCTACTAAAGTAGATAAGCATGTCTTACGGTCA
TACGTAAACTATGTTCCCCAAACACCATACATCTTCTCAGGAACAATCAAAGAAAATCTGCTCTTAGGTAGTCGACCAGA
TATTACAGAAAAAGATATATTGAAAGCCTGTCAGATAGCAGAAATTGAGTCTGAAATCGAACAATTACCACTGCAGTTTG
AAACCAAGATGGATGAAAATGCCAAGATTTTATCCGGTGGGCAAAAGCAAAGGCTAACTATTGCACGTGCATTATTGTCA
CCGGCTAAAATTTTAATTTTTGATGAAGCCACTAGCGGGCTTGATACGATTACAGAGAAAAAAGTAGTAGATAATTTAAT
GAAATTAAAAGATAAAACGATTATTTTTATTGCTCATCGTTTAGCAATTGCACAAAGGACTAACAATATTGTGGTTGTAG
ATCATGGTCAAATTGTTGAGCAAGGAAGTCATGAGAAATTAATGCAGAAACATGGCTTTTACTATAACTTAGTTGAGAAT
TAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(171-440)

Peptidase C39 family (Peptidase_C39)

(9-144)

ABC transporter (ABC_tran)

(502-652)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis SK321

56.783

99.306

0.564
  comA Streptococcus pneumoniae D39

56.643

99.306

0.562
  comA Streptococcus pneumoniae R6

56.643

99.306

0.562
  comA Streptococcus mitis NCTC 12261

56.643

99.306

0.562
  comA Streptococcus pneumoniae Rx1

56.643

99.306

0.562
  comA Streptococcus pneumoniae TIGR4

56.503

99.306

0.561
  comA Streptococcus gordonii str. Challis substr. CH1

55.804

99.306

0.554
  comA/nlmT Streptococcus mutans UA159

53.814

98.333

0.529