Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   LK450_RS05110 Genome accession   NZ_CP085939
Coordinates   1055873..1056625 (-) Length   250 a.a.
NCBI ID   WP_003031098.1    Uniprot ID   A0A3S4NJA6
Organism   Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1050873..1061625
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK450_RS05090 (LK450_05090) - 1051305..1052537 (-) 1233 WP_003031066.1 cysteine desulfurase -
  LK450_RS05095 (LK450_05095) sufD 1052553..1053815 (-) 1263 WP_003031089.1 Fe-S cluster assembly protein SufD -
  LK450_RS05100 (LK450_05100) sufC 1053855..1054625 (-) 771 WP_003025885.1 Fe-S cluster assembly ATPase SufC -
  LK450_RS05105 (LK450_05105) - 1054716..1055882 (-) 1167 WP_018543634.1 glycosyltransferase family 4 protein -
  LK450_RS05110 (LK450_05110) mecA 1055873..1056625 (-) 753 WP_003031098.1 adaptor protein MecA Regulator
  LK450_RS05115 (LK450_05115) - 1056749..1057591 (-) 843 WP_003031068.1 undecaprenyl-diphosphate phosphatase -
  LK450_RS05120 (LK450_05120) - 1057658..1059547 (-) 1890 WP_003031084.1 DUF2207 domain-containing protein -
  LK450_RS05125 (LK450_05125) - 1059674..1061239 (+) 1566 WP_003031063.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 28968.85 Da        Isoelectric Point: 4.1610

>NTDB_id=621410 LK450_RS05110 WP_003031098.1 1055873..1056625(-) (mecA) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDMEAVRSLETAEADDNTSTSDMESEENSDELTQKYIYYIL
KFSSLKEAIVFSKTVDYAVNTSELYKMDDHYYLTILVDIEGRPKRYPAWLLALMREHAEDTDVTRAVLQEHGYLLLVNEA
VASLKKVKCL

Nucleotide


Download         Length: 753 bp        

>NTDB_id=621410 LK450_RS05110 WP_003031098.1 1055873..1056625(-) (mecA) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAAATCACAATAAAATTAGAGGATTTAGAGGAACGTGGGATGGAAAT
GGCAGATTTTCTAGTCCCACAAGAAAAAACAGAAGAGTTTTTCTATGCGATTTTAGATGAGTTGGAAATGCCAGAGAGCT
TTTTAGATAGTGGCATGCTCAGTTTTCGTGTGACACCAAAGCCCGACCGATTGGATGTCTTTGTCACCAAGTCTAAGATT
GATAAGAATTTAAACTTCGATGATTTGGCAGATTTGCCAGATGTAGAAGAGTTGTCTCAAATGTCTCCTGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGTAAAGACGATATGGAGGCTGTTCGTTCTTTGGAAACGGCGGAAGCAG
ACGATAACACAAGCACTTCTGATATGGAGTCAGAGGAAAATAGTGACGAACTAACGCAGAAATATATTTATTACATTTTG
AAATTTTCCAGCCTGAAAGAAGCAATTGTTTTTTCTAAGACAGTAGATTATGCTGTCAATACTTCGGAGTTGTACAAAAT
GGACGACCACTATTATTTGACAATCTTGGTTGATATTGAAGGGCGTCCAAAGCGTTATCCAGCTTGGCTCCTGGCTTTGA
TGCGTGAACATGCAGAAGATACGGATGTGACAAGAGCTGTTTTGCAAGAGCACGGTTACTTATTGCTTGTCAACGAGGCG
GTTGCCAGTCTTAAAAAGGTTAAATGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3S4NJA6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

65.992

98.8

0.652
  mecA Streptococcus pneumoniae D39

65.992

98.8

0.652
  mecA Streptococcus pneumoniae R6

65.992

98.8

0.652
  mecA Streptococcus pneumoniae TIGR4

65.587

98.8

0.648
  mecA Streptococcus mutans UA159

50.201

99.6

0.5
  mecA Streptococcus thermophilus LMD-9

45.49

100

0.464
  mecA Streptococcus thermophilus LMG 18311

45.098

100

0.46