Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SIR_RS16685 Genome accession   NC_022246
Coordinates   1436101..1436850 (-) Length   249 a.a.
NCBI ID   WP_021003094.1    Uniprot ID   T1ZFU7
Organism   Streptococcus intermedius B196     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1431101..1441850
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS16665 (SIR_1361) - 1431526..1432758 (-) 1233 WP_021003091.1 cysteine desulfurase -
  SIR_RS16670 (SIR_1362) sufD 1432775..1434037 (-) 1263 WP_021003092.1 Fe-S cluster assembly protein SufD -
  SIR_RS16675 (SIR_1363) sufC 1434077..1434847 (-) 771 WP_009568102.1 Fe-S cluster assembly ATPase SufC -
  SIR_RS16680 (SIR_1364) - 1434938..1436104 (-) 1167 WP_003073746.1 glycosyltransferase family 4 protein -
  SIR_RS16685 (SIR_1365) mecA 1436101..1436850 (-) 750 WP_021003094.1 adaptor protein MecA Regulator
  SIR_RS16690 (SIR_1366) - 1436977..1437819 (-) 843 WP_003073751.1 undecaprenyl-diphosphate phosphatase -
  SIR_RS16695 (SIR_1367) - 1437886..1439775 (-) 1890 WP_021003095.1 DUF2207 domain-containing protein -
  SIR_RS16700 (SIR_1368) - 1439902..1441467 (+) 1566 WP_021003096.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 28934.66 Da        Isoelectric Point: 4.1860

>NTDB_id=61895 SIR_RS16685 WP_021003094.1 1436101..1436850(-) (mecA) [Streptococcus intermedius B196]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDIEAVRSLETAEAENSRSTSDVEEQEEDNDELTQKYIYYI
LKFANLREVIVFAKTVDYTVNTSELYKMDSHYYLTILVDIEGHPKRYPAWLLASMREHAEDTAVTRAVLQEHGYLLLVND
AVSNLQKVK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=61895 SIR_RS16685 WP_021003094.1 1436101..1436850(-) (mecA) [Streptococcus intermedius B196]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAAATCACAATAAAATTAGAAGATTTAGAAGAACGTGGAATGGAGAT
GGCAGATTTTCTCGTTCCGCAAGAAAAGACAGAAGAGTTTTTCTATGCAATTTTAGATGAGTTGGAAATGCCAGAGAGTT
TTTTGGATAGCGGTATGCTCAGTTTTCGTGTAACCCCTAAACCAGACCGACTGGATGTTTTTGTCACCAAGTCTAAGATT
GATAAGAATCTGAACTTTGATGATTTAGCAGATTTACCAGATGTAGAAGAGCTGTCTCAAATGTCTCCAGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGCAAAGACGATATTGAAGCTGTTCGGTCTTTAGAAACGGCAGAAGCAG
AAAATAGTAGAAGCACTTCTGATGTGGAAGAACAAGAGGAAGATAATGACGAGCTAACACAAAAATATATATATTACATT
TTGAAGTTTGCCAACCTAAGAGAAGTGATTGTTTTTGCTAAAACGGTAGATTATACCGTCAATACTTCAGAGTTATACAA
AATGGACAGTCACTATTATTTGACAATTTTGGTTGATATTGAAGGCCATCCTAAGCGATATCCGGCTTGGCTTCTTGCAT
CTATGCGTGAACATGCAGAAGATACAGCTGTGACAAGAGCTGTTTTGCAAGAGCATGGTTACTTATTGCTTGTCAACGAT
GCGGTTTCCAATCTTCAAAAGGTTAAATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZFU7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.145

99.598

0.679
  mecA Streptococcus pneumoniae D39

68.145

99.598

0.679
  mecA Streptococcus pneumoniae R6

68.145

99.598

0.679
  mecA Streptococcus pneumoniae TIGR4

67.742

99.598

0.675
  mecA Streptococcus mutans UA159

51.613

99.598

0.514
  mecA Streptococcus thermophilus LMD-9

46.094

100

0.474
  mecA Streptococcus thermophilus LMG 18311

45.703

100

0.47

Multiple sequence alignment