Detailed information NTG0618808

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NW341_RS12320
• Genome accession: NZ_CP102946
• Coordinates: 2590042..2590713 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain SCAID WND1-2022 (148)
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2585042..2595713

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW341_RS12285 (NW341_12285)	ppyR	2585515..2585772 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
NW341_RS12290 (NW341_12290)	-	2585759..2586952 (+)	1194	WP_003122598.1	NnrS family protein	-
NW341_RS12295 (NW341_12295)	-	2586953..2587219 (-)	267	WP_003115326.1	DUF5329 domain-containing protein	-
NW341_RS12300 (NW341_12300)	-	2587203..2588096 (-)	894	WP_003131077.1	hypothetical protein	-
NW341_RS12305 (NW341_12305)	-	2588123..2589205 (-)	1083	WP_003113385.1	hypothetical protein	-
NW341_RS12310 (NW341_12310)	-	2589420..2589728 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
NW341_RS12315 (NW341_12315)	-	2589728..2590042 (+)	315	WP_003097704.1	PepSY domain-containing protein	-
NW341_RS12320 (NW341_12320)	ciaR	2590042..2590713 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
NW341_RS12325 (NW341_12325)	carS	2590710..2592047 (+)	1338	WP_003090493.1	two-component system sensor histidine kinase CarS	-
NW341_RS12330 (NW341_12330)	-	2592138..2592446 (+)	309	WP_003113384.1	hypothetical protein	-
NW341_RS30310	-	2592451..2592987 (-)	537	Protein_2440	methyl-accepting chemotaxis protein	-
NW341_RS30315	-	2593357..2594595 (-)	1239	Protein_2441	chemotaxis protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=618808 NW341_RS12320 WP_003090494.1 2590042..2590713(+) (ciaR) [Pseudomonas aeruginosa strain SCAID WND1-2022 (148)]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=618808 NW341_RS12320 WP_003090494.1 2590042..2590713(+) (ciaR) [Pseudomonas aeruginosa strain SCAID WND1-2022 (148)]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAACCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GCTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363